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Jan 18, 2019 · In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter.
- Kevin R. Campos, Paul J. Coleman, Juan C. Alvarez, Spencer D. Dreher, Robert M. Garbaccio, Nicholas ...
- 2019
Jun 22, 2021 · As such, the development of new synthetic methods can have major impacts on the pharmaceutical industry, not only by increasing overall efficiency but also by enabling access to novel...
- Kaitlyn Lovato, Patrick S. Fier, Kevin M. Maloney
- 2021
Jan 18, 2019 · Of particular interest are new synthetic methods that enable medicinal chemists to control reactivity in complex, drug-like molecules, access non-obvious vectors for SAR development, and rapidly access new chemical space or unique bond formations.
- Kevin R. Campos, Paul J. Coleman, Juan C. Alvarez, Spencer D. Dreher, Robert M. Garbaccio, Nicholas ...
- 2019
Mar 22, 2018 · There is clear evidence that new synthetic methodology published by academics can spark the pharmaceutical industry to make and explore structures that were previously inaccessible.
- David C. Blakemore, Luis Castro, Ian Churcher, David C. Rees, Andrew W. Thomas, David M. Wilson, Ant...
- 2018
Sep 4, 2023 · As far as we know, the study of the synthetic methods of new chemical molecules and their mechanisms of action in clinical applications will greatly promote the development of new drugs, and the summary of newly introduced drugs will provide innovative and practical inspiration for new drug discovery [10,11,12,13,14,15,16,17,18,19,20].
Moreover, recent devel-opments in new synthetic methods, biocatalysis, chemoinformatics, and reaction miniaturiza-tion have the power to accelerate the pace and improve the quality of products in pharma-ceutical research.
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Nov 20, 2018 · The pharmaceutical industry, driven by an increasing need to deliver new and more effective medicines to patients, is increasingly turning to the use of engineered biocatalysts for both lead...
