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For ADHD core symptoms rated by clinicians in children and adolescents closest to 12 weeks, all included drugs were superior to placebo (eg, SMD –1·02, 95% CI –1·19 to –0·85 for amphetamines, –0·78, –0·93 to –0·62 for methylphenidate, –0·56, 0·66 to –0·45 for atomoxetine).
- Overview
- Attention Deficit Hyperactivity Disorder
- Narcolepsy
- Frequently asked questions
- More about Adderall (amphetamine / dextroamphetamine)
- Further information
Generic name: DEXTROAMPHETAMINE SACCHARATE 1.25mg, AMPHETAMINE ASPARTATE MONOHYDRATE 1.25mg, DEXTROAMPHETAMINE SULFATE 1.25mg, AMPHETAMINE SULFATE 1.25mg
Dosage form: tablet
Drug class: CNS stimulants
Regardless of indication, amphetamines should be administered at the lowest effective dosage, and dosage should be individually adjusted according to the therapeutic needs and response of the patient. Late evening doses should be avoided because of the resulting insomnia.
•for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) (see WARNINGS).
•the family history and clinically evaluate patients for motor or verbal tics or Tourette’s syndrome before initiating Adderall® (see WARNINGS).
Not recommended for children under 3 years of age. In children from 3 to 5 years of age, start with 2.5 mg daily; daily dosage may be raised in increments of 2.5 mg at weekly intervals until optimal response is obtained.
In children 6 years of age and older, start with 5 mg once or twice daily; daily dosage may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg per day. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.
Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.
Prior to treating patients with Adderall® assess:
•for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam) (see WARNINGS).
•the family history and clinically evaluate patients for motor or verbal tics or Tourette’s syndrome before initiating Adderall® (see WARNINGS).
Usual dose 5 mg to 60 mg per day in divided doses, depending on the individual patient response.
Narcolepsy seldom occurs in children under 12 years of age; however, when it does, dextroamphetamine sulfate may be used. The suggested initial dose for patients aged 6 to 12 is 5 mg daily; daily dose may be raised in increments of 5 mg at weekly intervals until optimal response is obtained. In patients 12 years of age and older, start with 10 mg daily; daily dosage may be raised in increments of 10 mg at weekly intervals until optimal response is obtained. If bothersome adverse reactions appear (e.g., insomnia or anorexia), dosage should be reduced. Give first dose on awakening; additional doses (1 or 2) at intervals of 4 to 6 hours.
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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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Oct 15, 2024 · The American Academy of Pediatrics (AAP) has developed a clinical practice guideline that provides recommendations for the diagnosis and treatment of children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
Jan 28, 2021 · At the end of a 6-week, open-label, dose-optimization period in one study, the mean daily optimized dose was 66.2 mg (SD=19.56) . Although the FDA-recommended starting dose is 20 mg, most patients will not achieve optimal symptom control until higher doses are prescribed.
• Long-acting stimulant medications are generally preferred for school-aged children. • Start with a first line medication from the methylphenidate or dextroamphetamine- amphetamine class.
Sleep disturbance. Assess, optimize sleep hygiene, bedtime routines. Assess for other sleep disorders. If using IR form: decrease or eliminate PM dose, or give earlier. If using ER form: Administer earlier in AM, or switch to short-acting form.
Mar 15, 2011 · Children six years and older: 30 mg in morning. Increase weekly in increments of 10 to 20 mg per day, to a maximum dosage of 70 mg per day. Insomnia, headache, nervousness, dizziness,...
