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- Each generation, the germline cycles through the following phases: specification of the primordial germ cells (the precursors of gametes) during embryogenesis; proliferation, meiosis, and differentiation into gametes during later stages of development; and, finally, fusion between an egg and sperm to produce a new, totipotent zygote (Lesch and Page, 2012).
www.ncbi.nlm.nih.gov/pmc/articles/PMC7572804/
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How do germ cells develop and function?
How does phase separation drive the essential steps during germline development?
What is the germinal stage of development?
What happens during the germinal stage of a zygote?
How long does the germinal stage last?
Do early embryonic germ granules promote germ cell fate?
The germinal stage lasts a total of eight to nine days. It begins in a Fallopian tube when an ovum is fertilized by a sperm to form a zygote (day 0). The germinal stage continues as the zygote undergoes several initial cell divisions to form a solid ball of cells called a morula (days 3-4).
Here, we discuss the organization, dynamics, and potential functions of phase-separated compartments in germ cells and examine the various ways in which phase separation might contribute to the development of multicellular organisms.
- Anne E. Dodson, Scott Kennedy
- 2020
Phase separation controls the assembly and segregation of germ granules that determine which embryonic cells become germ cells. Phase separation promotes the formation of the Balbiani body, a structure that stores organelles and RNAs during the prolonged prophase arrest of oocytes.
- Chun So, Shiya Cheng, Melina Schuh
- 2021
How germ cells develop, function, and eventually give rise to entirely new organisms is an important question in biology. A growing body of evidence suggests that phase separation events likely play a significant and multifaceted role in germ cells and development.
- 1MB
- Anne E. Dodson, Scott Kennedy
- 14
- 2020
Oct 2, 2020 · Here, we discuss the organization, dynamics, and potential functions of phase-separated compartments in germ cells and examine the various ways in which phase separation might contribute to the development of multicellular organisms.
- Anne E. Dodson, Scott Kennedy
- 2020
Oct 10, 2020 · Here, we discuss the organization, dynamics, and potential functions of phase-separated compartments in germ cells and examine the various ways in which phase separation might contribute to the development of multicellular organisms.
Jan 14, 2021 · Phase separation controls the assembly and segregation of germ granules that determine which embryonic cells become germ cells. Phase separation promotes the formation of the Balbiani body, a structure that stores organelles and RNAs during the prolonged prophase arrest of oocytes.
