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  1. U.S. Route 50 (US 50) runs east–west across the southern part of the state of Ohio, passing through Cincinnati, Chillicothe, and Athens. It is mainly a two-lane road except for the easternmost and westernmost parts. Near Athens it runs concurrently with State Route 32 (SR 32), a four-lane divided highway known as Corridor D, and from ...

  2. Apr 23, 2024 · U.S. Route 50 is a 3,200-mile road that spans 11 states and showcases some of America’s most beautiful scenery -- especially in Ohio. This route winds its way through the entire southern portion of Ohio, showing off some of the Buckeye State's best rural scenery and most charming small towns.

  3. A road trip along US-50 follows time from colonial-era landscapes through the Wild West to high-tech Silicon Valley, the best route for the unhurried.

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  4. Aug 4, 2021 · A Drive Down Ohios Loneliest Road Will Take You Miles And Miles Away From It All. US Route 50, known as "The Loneliest Road In America," offers a scenic drive through Ohio's rural landscapes and small towns.

  5. Travel US 50 through Ohio, OH. The Buckeye State. The Heart of It All! Columbus is the Capital. State motto is: With God, all things are possible.

  6. AMERICA'S GREENEST AIRLINE powered by PRATT & WHITNEY GTFTM ENGINES. View a map of destination cities served by Frontier Airlines and its partners.

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  8. The 210 mi (340 km) US-50 takes to cross the state are a fairly constant mix of upland forest and bottomland farms, with a single industrial district in the middle around Chillicothe, and a refreshing small college town, Athens, farther east. Map of the Loneliest Road through Ohio. Buy Now.

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