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  1. Acute toxicity describes the adverse effects of a substance that result either from a single exposure [1] or from multiple exposures in a short period of time (usually less than 24 hours). [2] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance. [2]

  2. DEFINITIONS. 1. Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours. CLASSIFICATION CRITERIA FOR SUBSTANCES. 2.

  3. Definition. Poisoning or overdose: What is it? Last revised in March 2024. In toxicology, poisoning is defined as the state resulting from the administration of excessive amounts of any pharmaceutical agent [WHO, 2014]. A poison may be a drug, household product, industrial chemical, or plant or animal derivative [NPIS, 2021].

  4. Introduction. IOGP Fatality and Permanent Impairment (FPI) injury definitions are designed for use in energy industry reporting. They are deliberately concise and concept based. Examples and an associated Frequently Asked Questions resource will help support specific case decision making.

    • ALARP Explained
    • ALARP and SFAIRP
    • How We Use ALARP
    • Why Do I Need to Know About ALARP?
    • What Is Meant by Reasonably Practicable?
    • Hazard Or Risk?
    • How to Tell If A Risk Is ALARP
    • Some Fallacies About ALARP
    • Useful Links and Divisional Contacts

    This guide has been produced to explain the concept of "reasonably practicable" in a simple way for HSE staff and incorporates guidance currently held on HSE's website. It's aimed mainly at staff new to HSE and those new to decision making.

    "ALARP" is short for "as low as reasonably practicable". "SFAIRP" is short for "so far as is reasonably practicable". The two terms mean essentially the same thing and at their core is the concept of "reasonably practicable"; this involves weighing a risk against the trouble, time and money needed to control it. Thus, ALARP describes the level to w...

    Using "reasonably practicable" allows us to set goals for duty-holders, rather than being prescriptive. This flexibility is a great advantage but it has its drawbacks, too. Deciding whether a risk is ALARP can be challenging because it requires duty-holders and us to exercise judgement. In the great majority of cases, we can decide by referring to ...

    The concept of "reasonably practicable" lies at the heart of the British health and safety system. It is a key part of the general duties of the Health and Safety at Work etc. Act 1974 and many sets of health and safety regulations that we and Local Authorities enforce. HSC's policy is that any proposed regulatory action (Regulations, ACOPs, guidan...

    You may come across it as SFAIRP ("so far as is reasonably practicable") or ALARP ("as low as reasonably practicable"). SFAIRP is the term most often used in the Health and Safety at Work etc Act and in Regulations. ALARP is the term used by risk specialists, and duty-holders are more likely to know it. We use ALARP in this guidance. In HSE's view,...

    Definition of a hazard

    A hazard is something (eg an object, a property of a substance, a phenomenon or an activity) that can cause adverse effects. For example: 1. Water on a staircase is a hazard, because you could slip on it, fall and hurt yourself. 2. Loud noise is a hazard because it can cause hearing loss. 3. Breathing in asbestos dust is a hazard because it can cause cancer.

    Definition of a risk

    A risk is the likelihood that a hazard will actually cause its adverse effects, together with a measure of the effect. It is a two-part concept and you have to have both parts to make sense of it. Likelihoods can be expressed as probabilities (eg "one in a thousand"), frequencies (eg "1000 cases per year") or in a qualitative way (eg "negligible", "significant", etc.). The effect can be described in many different ways. For example: 1. The annual risk of a worker in Great Britain experiencing...

    Using "reasonably practicable" allows us to set goals for duty-holders, rather than being prescriptive. This flexibility is a great advantage. It allows duty-holders to choose the method that is best for them and so it supports innovation, but it has its drawbacks, too. Deciding whether a risk is ALARP can be challenging because it requires duty-ho...

    Some myths or fallacies about what ALARP means have grown up over the years. Here we explain what some of these myths are and, why they are wrong.

    Directorate/Divisional ALARP guidance

    Some parts of HSE have also produced supplementary ALARP guidance that put the issues in context for different sectors: Offshore

    Useful documentation

    HSE has also published a document that sets out how we use risk ideas to take decisions about heath and safety regulation. While not written as guidance, it summarises some of the important concepts relating to ALARP: Reducing Risks, Protecting People (PDF) (88 pages)

  5. A valid, reliable, and repeatable classifi cation scheme to evaluate incidents for SIF Exposure Potential. SIF and SIF Exposure Potential Defi ned. Each organization must defi ne how broadly it wants to defi ne the “serious injury” part of “fatalities and serious injuries.”

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  7. Learn about the factors that affect your risk of being exposed to COVID-19, including ventilation, filtration, masks, distance, and exposure time.

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