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1. www.ncbi.nlm.nih.gov › pmc › articlesPLCOjs, a FAIR GWAS web SDK for the NCI Prostate, Lung ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Sep 9, 2022 · As demonstrated in this report, the reliance on portable client-side web SDKs is equally compelling for large complex studies such as genome-wide association studies (GWASs) that generate millions of association statistics of traits with genotypes ( Machiela and Chanock, 2018 ), such as the PLCO Genetic Atlas Project.

   • DOI: 10.1093/bioinformatics/btac531

   • Published: 2022/09/09

2. www.nature.com › articles › ncomms11843Female chromosome X mosaicism is age-related and ... - Nature

   www.nature.com › articles › ncomms11843

   Jun 13, 2016 · Abstract. To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases...

   • Author: Mitchell J. MacHiela, Weiyin Zhou, Eric Karlins, Joshua N. Sampson, Neal D. Freedman, Qi Yang, Belyn...

   • Publish Year: 2016

3. www.nature.com › articles › s41467/018/05537-2Genome-wide association study identifies multiple new loci ...

   www.nature.com › articles › s41467/018/05537-2

   Aug 9, 2018 · Ewing sarcoma (EWS) is a rare pediatric bone cancer typically involving the EWSR1-FLI1 fusion. Here the authors perform a genome-wide association study and report three new EWS risk loci that ...

   • Author: Mitchell J Machiela, Thomas G P Grünewald, Thomas G P Grünewald, Didier Surdez, Stephanie Reynaud, O...

   • Publish Year: 2018

4. pubmed.ncbi.nlm.nih.gov › 36927626Mosaic chromosomal alterations detected in men living with ...

   pubmed.ncbi.nlm.nih.gov › 36927626

   We compared CH prevalence in men living with HIV (MLWH) to HIV-uninfected men using logistic regression, and among MLWH, assessed the associations of CH with NHL incidence and overall mortality using Poisson regression.

5. www.ncbi.nlm.nih.gov › pmc › articlesHematopoietic mosaic chromosomal alterations and risk for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 12, 2020 · Age-related mosaic chromosomal alterations (mCAs) detected from blood-derived DNA genotyping, are structural somatic variants associated with aberrant leukocyte cell counts, hematological malignancy, and mortality 3 – 11. Whether mCAs represent independent risk factors for infection is unknown.

   • Author: Seyedeh M Zekavat, Seyedeh M Zekavat, Seyedeh M Zekavat, Shu-Hong Lin, Alexander G Bick, Alexander G...
   • DOI: 10.1101/2020.11.12.20230821

   • Publish Year: 2020
   • Publication: Version 1. medRxiv. Preprint. 2020 Nov 16.

6. www.ncbi.nlm.nih.gov › pmc › articlesHematopoietic mosaic chromosomal alterations increase the ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic variants indicative of clonal hematopoiesis and are associated with aberrant leukocyte cell counts, hematological malignancy, and mortality. Here we show that mCAs predispose to diverse types of infections.

7. deainfo.nci.nih.gov › advisory › ncabIntegrative Population-Based Characterization of Mosaic ...

   deainfo.nci.nih.gov › advisory › ncab

   Mitchell J. Machiela, ScD MPH Earl Stadtman Investigator Integrative Tumor Epidemiology Branch Division of Cancer Epidemiology and Genetics