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Aug 15, 2022 · As Aβ and tau deposition induces ER stress, adaptive UPR signaling is activated to reverse ER stress and regain the ER homeostasis thereby preventing exacerbation of AD pathogenesis,...
Jan 9, 2020 · Consistent with this proposed detrimental role for IGF-1 signaling in AD, heterozygous deletion of the IGF-1 receptor partially rescues spatial memory impairment and synaptic loss in AD mouse models, potentially due to an associated reduction in soluble Aβ oligomers (Cohen et al., 2009).
- Sophie C Gray, Kerri J Kinghorn, Nathaniel S Woodling
- 10.4103/1673-5374.272571
- 2020
- Neural Regen Res. 2020 Jul; 15(7): 1208-1219.
Dec 2, 2022 · However, when the UPR is disrupted or insufficient, cell death occurs. This review examines the links between UPR signaling, cell-protective responses, and death following ER stress with a particular focus on those mechanisms that operate in neurons.
- Adalberto Merighi, Laura Lossi
- Int J Mol Sci. 2022 Dec; 23(23): 15186.
- 10.3390/ijms232315186
- 2022/12
Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's disease (AD) and by their caretakers. Working memory and long-term declarative memory are affected early during the course of the disease.
Jan 13, 2022 · Here, a shift in excitatory–inhibitory balance appears to lead to forgetting: the stimulation of MCH–hippocampal projections inhibited firing of hippocampal pyramidal cells, and was associated ...
Mar 1, 1999 · Clinical observation of Alzheimer's disease patients reveals that they often have great difficulty in performing everyday tasks at a relatively early stage in the disease when formal testing of non-memory functions, such as language, praxis and visuospatial abilities, show little or no deficit.
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Does a shift in excitatory–inhibitory balance lead to forgetting?
Is there a link between ER stress and maladaptive UPR?
Is ER stress a neuroprotective mechanism?
How does ER stress affect cell death?
How does Alzheimer's disease affect ER homeostasis?
Does disinhibition of engram cells lead to memory recall?
Apr 15, 2024 · A homeostatic model of memory processing. This model proposes that interactions between neural systems are geared towards reducing uncertainty and making adaptive decisions. This is facilitated through the signaling and transmission of various prediction errors.
