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The BoneXpert adult height prediction (AHP) method is the state-of-the art method to predict adult height from age, bone age, gender and current height. It is the natural successor to the classical
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1 Summary. The BoneXpert online Adult Height Predictor, www.BoneXpert.com/ahp underwent a major update on 12 Feb 2021 to version 3.0. This whitepaper gives the clinical background for the update, including its development and validation. The main improvements in version 3 are: The Caucasian model has been extended down to bone age 2 years, and ...
The BoneXpert adult height prediction (AHP) method is a new and improved AHP method with better accuracy than the conventional Tanner-Whitehouse-3 (TW3) and Bayley-Pinneau (BP) methods commonly used by paediatric endocrinologists and paediatric radiologists [1-3].
BoneXpert uses a new method, called the BoneXpert Adult Height Prediction method version 3.0, which is a modernisation and extension of the Bayley-Pinneau method from 1952. It uses the current height, age, bone age, and gender to predict adult height.
- The First Generation – Bayley–Pinneau
- The Second Generation – Tanner
- The Third Generation – Roche
- The Fourth Generation – BoneXpert
- Previous Comparative Studies
- Chapter Outline
- Data Used in This Work
The first AHP model was formulated by Bayley (Bayley, 1946) and was based on Todd’s method for the determination of BA. The Greulich–Pyle (GP) BA method is a refinement of Todd’s atlas method, and both are based on data from the Brush Foundation study of children from Ohio. The GP atlas (Greulich and Pyle, 1959) contains plates corresponding to a s...
In Europe, an alternative to the American GP/BP system was developed by Tanner and co-workers. The first description of the Tanner–Whitehouse (TW) skeletal maturity assessment system appeared in 1962 (Tanner et al., 1962). It was based on 20 bones. The operator assigns maturity stages A, B, .., I to each bone, and the TW system defines a score to e...
Roche and collaborators developed the third BA method, the Fels method, in 1988 (Roche et al., 1988). This method was based on the Fels longitudinal study which has recruited, on average, 18 children per year since 1933. This method is similar to the TW method but involves more bones, more maturity features, and more advanced mathematics. The Fels ...
Despite the early recognition by many, in particular Tanner (1989), that BA assessment was a task well suited for computerization, it took more than 20 years to realize this vision. The complexity in the development of such a method was underestimated, and only by using very advanced mathematical methods and taking advantage of the 10,000-fold incr...
These competing methods, which were used for the same prediction, led to a number of comparative studies, including the five which we will now discuss. In 1978, the three existing methods were validated on both normal children from the 1ZLS and children with Turner syndrome (Zachmann et al., 1978); however, the Turner syndrome children were outside...
The seven AHP models all use current height h, age, BA, and gender to predict adult height H. They differ mainly in the following three aspects: 1. The type of BA, i.e. the weight assigned to different bones, and the reliability of the BA rating. 2. The population used for the estimation of the model and for its validation, e.g. the range of variat...
Many aspects of AHP will be illustrated with the data used to develop and validate the BX method. These data, which are summarized in Table 3.2, are described in this section. The results on the Zürich studies have been reported previously (Thodberg et al., 2009a), while the results on the Björk study are new. The 1ZLS of growth (Prader et al., 198...
- Hans Henrik Thodberg, Anders Juul, Jens Lomholt, David D. Martin, Oskar G. Jenni, Jon Caflisch, Mich...
- 2012
Sep 21, 2023 · All models overestimated the population mean (males: 0.7–6.7 cm, females: 0.9–3.7 cm). The AHP models with the smallest difference were BoneXpert for males and Bayley & Pinneau for females.
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TLDR. The new method for adult height prediction has become objective because the dependence on manual bone age rating is eliminated and is well-suited to analyze large studies and provide a consistent body of evidence regarding the relation between maturation, body mass, and growth across populations, conditions, and ethnicities. Expand.
