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  2. It's rare, but statins can sometimes cause muscle inflammation (swelling) and damage. Speak to your doctor if you have muscle pain, tenderness or weakness that cannot be explained – for example, pain that is not caused by physical work.

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      Atorvastatin Brand name: Lipitor. Find out how atorvastatin...

    • Considerations

      Statins are also more likely to cause muscle damage in...

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    • Uses

      Statins may be recommended if you have cardiovascular...

    • What Statin Intolerance Means
    • Check For Interactions
    • Try A Different Statin
    • Take A Lower Dose
    • Try A Different Option

    People who are statin intolerant are unable to tolerate the lowest dose of two or more statins, due to the adverse effects that they have on the muscles, joints or liver. Within a month of starting statin therapy, they may feel aches or weakness in the large muscles of their arms, shoulders, thighs or buttocks on both sides of the body. About 5 to ...

    Sometimes, certain foods or medications prevent the body from eliminating statins at the normal rate, causing statin levels in the body to rise. The most common culprits include: 1. Heavy alcohol consumption. 2. The calcium-channel blockers diltiazem and verapamil. 3. The antiarrhythmic drugs amiodarone and digoxin. 4. Antibiotics ending in -mycin....

    Most statins are lipophilic, which means they passively diffuse into the muscle. These statins, including atorvastatin (Lipitor®), simvastatin (Zocor®) and fluvastatin (Lescol®), are more likely to cause muscle aches. The hydrophilic statins, including rosuvastatin (Crestor®) and pravastatin (Pravachol®), have to be actively transported and cause f...

    A little statin is better than none, so try taking the lowest dose of a hydrophilic statin once a week. For example, start with rosuvastatin 2.5 mg on Mondays. If you can tolerate it, add 2.5 mg on Thursdays. If that doesn’t bother you, add a third day. Another option is to stay on the twice-weekly schedule and raise the dose to 5 mg. “By introduci...

    If you’re still unable to tolerate any statins at all, ask about switching to exetimibe (Zetia®), which can lower LDL by 15%, or a PCSK9 inhibitor. There are two: alirocumab (Praluent®) and evolocumab (Repatha®). These powerful drugs can lower LDL to rock-bottom levels without triggering muscle pain. The only disadvantage is price. PCSK9 inhibitors...

  3. An international team of BHF-funded researchers may have discovered why a small number of people experience muscle pain after taking statins. The research could help doctors prevent a known side effect of statins and ensure people are able to reap the benefits of the life-saving drugs.

  4. Mar 5, 2021 · Statin muscle pain may be the result of tissue damage, or it could be due to the "nocebo" effect. Read on to learn about some potential ways to alleviate it.

  5. Jul 18, 2024 · One of the most commonly reported by people who take statins: muscle pain called statin-induced myopathy, also referred to as statin-associated muscle symptoms, or SAMS. It’s a major reason...

  6. you have a weakness in your arms or legs that gets worse after activity, or if you get double vision, drooping eyelids, problems swallowing or shortness of breath - these can be a sign of mysathenia gravis. Call 999 now or go to A&E if: you develop severe breathing or swallowing problems.

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