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  1. Jul 10, 2023 · This review aims to comprehensively analyze the opioid epidemic in the United States by identifying the contributing factors and negative consequences as well as best practices for healthcare providers in managing the crisis.

  2. The medical dictum primum non nocere (first, do no harm) is usually attributed to Hippocrates, and a poignant modern example of the injunction’s warning lies in the balance between the legitimate value and inappropriate use of the substances derived from the opium poppy plant.

    • National Academy of Medicine
    • 2017
  3. The current opioid epidemic is one of the most severe public health crisis in US history. Responding to it has been difficult due to its rapidly changing nature and the severity of its associated outcomes.

    • Nora D. Volkow, Carlos Blanco
    • 10.1038/s41380-020-0661-4
    • 2021
    • 2021/01
  4. Apr 5, 2024 · The number of opioid-related deaths has been rising continuously since 1999. Three distinct waves of increases are related to different types of opioids throughout the last 25 years. Increasing communities' support, capacity, and education may help turn the tide and prevent overdose deaths.

    • Key Facts
    • Opioids
    • Opioid Overdose
    • Risk Factors For Opioid Overdose
    • Emergency Responses to Opioid Overdose
    • People Most Likely to Witness An Opioid Overdose
    • Prevention of Opioid Overdose
    • Who Response and Recommendations
    The term “opioids” includes compounds that are extracted from the poppy plant (Papaver somniferum)as well as semisynthetic and synthetic compounds with similar properties that can interact with opi...
    Opioids are commonly used for the treatment of pain, and include medicines such as morphine, fentanyl and tramadol.
    Their non-medical use, prolonged use, misuse and use without medical supervision can lead to opioid dependence and other health problems.
    Due to their pharmacological effects, opioids can cause breathing difficulties, and opioid overdose can lead to death.

    The term “opioids” includes compounds that are extracted from the poppy plant (Papaver somniferum) as well as semisynthetic and synthetic compounds with similar properties that can interact with opioid receptors in the brain. Opioids have analgesic and sedative effects, and such medicines as morphine, codeine and fentanyl are commonly used for the ...

    Opioid use can lead to death due to the effects of opioids on the part of the brain which regulates breathing. An opioid overdose can be identified by a combination of three signs and symptoms: 1. pinpoint pupils 2. unconsciousness 3. difficulties with breathing. Worldwide, about 600 000 deaths were attributable to drug use in 2019. Close to 80% of...

    There are a number of risk factors for opioid overdose. These include: 1. having an opioid use disorder; 2. taking opioids by injection; 3. resumption of opioid use after an extended period of abstinence (e.g. following detoxification, release from incarceration, cessation of treatment); 4. using prescription opioids without medical supervision; 5....

    Death following opioid overdose is preventable if the person receives basic life support and the timely administration of the drug naloxone. Naloxone is an antidote to opioids that will reverse the effects of an opioid overdose if administered in time. Naloxone has virtually no effect in people who have not taken opioids. Access to naloxone is gene...

    People who are most likely to witness an opioid overdose are: 1. people at risk of an opioid overdose themselves; 2. friends and families of people who use opioids on a regular basis; and 3. health-care workers, the emergency services, people providing accommodation to people who use opioids, and peer education and outreach workers as well as other...

    Beyond approaches to reducing drug use in general in the community, there are specific measures to prevent opioid overdose. These include: 1. increasing the availability of opioid dependence treatment, including for those dependent on prescription opioids; 2. reducing and preventing irrational or inappropriate opioid prescribing; 3. monitoring opio...

    WHO supports countries in their efforts to ensure rational use of opioids and their optimal availability for medical purposes and minimization of their misuse and non-medical use. Following the recommendation of WHO’s Expert Committee on Drug Dependence (6), a number of synthetic opioids, including fentanyl analogues, have been placed under interna...

  5. As a result, 60,000,000 people struggle with the addictive effects of opioids globally and more than 100,000 people die every year of opioid overdose, many of them with fentanyl, an analgesic drug that is 50–100 times more potent than heroin or morphine.

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  7. There is no question that opioid use disorder has become the fastest growing, serious, and far-reaching public health crisis facing our nation today. The growing and unprecedented opioid epidemic is a critical issue for public health and medical care throughout the country.

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