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      • Anxiety and depressive disorders are moderately heritable (approximately 40%), and evidence suggests shared genetic risk across the internalizing disorders (10). Among internalizing disorders, the highest level of shared genetic risk appears to be between major depressive disorder and generalized anxiety disorder.
      psychiatryonline.org/doi/10.1176/appi.ajp.2020.20030305

      The Critical Relationship Between Anxiety and Depression

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  3. www.nature.com › articles › s41380/023/01957-9The genetic basis of major depressive disorder | Molecular ...

    Jan 26, 2023 · The genetic dissection of major depressive disorder (MDD) ranks as one of the success stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying 178 genetic risk...

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  4. pmc.ncbi.nlm.nih.gov › articles › PMC9232544Genetic and epigenetic factors associated with depression: An ...

    Increasing evidence indicates that epigenetic modification is critical in the biological mechanisms of depression, and DNA methylation has been considered a potential link among the environment and depression.

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  6. www.psychologytoday.com › us › blogIn Sight: The Biological Diagnosis of Depression and Anxiety

    Jun 19, 2024 · New research identifies six biotypes of depression and anxiety, based on brain network activity and clinical features.

  7. psychiatryonline.org › doi › 10The Critical Relationship Between Anxiety and Depression

    May 1, 2020 · A European community-based study revealed, beginning at age 15, the developmental relation between comorbid anxiety and major depression by specifically focusing on social phobia (based on DSM-IV criteria) and then asking the question regarding concurrent major depressive disorder (18).

  8. pmc.ncbi.nlm.nih.gov › articles › PMC4309382Genetic determinants of depression: Recent findings and ...

    The overarching goal of this review paper is to translate recent findings from studies of genetic association and GxE related to depression, particularly for readers without in-depth knowledge of genetics or genetic methods. This review is organized into three major sections.

  9. www.health.harvard.edu › depression › how-genes-andHow genes and life events affect mood and depression

    Jan 10, 2022 · Many researchers believe that early trauma causes subtle changes in brain function that account for symptoms of depression and anxiety. The key brain regions involved in the stress response may be altered at the chemical or cellular level.

  10. www.cambridge.org › core › journalsGenetic contributions to anxiety disorders: where we are and ...

    Here we review current knowledge about the genetics of anxiety across the lifespan from genetically informative designs (i.e. twin studies and molecular genetics). We include studies of specific anxiety disorders (e.g. panic disorder, generalised anxiety disorder) as well as those using dimensional measures of trait anxiety.

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