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1. britishlivertrust.org.uk › liver-conditions › diliDrug induced liver injury (DILI) - British Liver Trust

   britishlivertrust.org.uk › liver-conditions › dili

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   If a medicine causes damage to your liver, this is called Drug Induced Liver Injury or DILI. Your liver has an amazing ability to repair itself when it has been damaged. So, most people will fully recover from drug induced liver injury. But recovery can take time.

2. www.bsg.org.uk › web-education › drug-induced-liverDrug-induced Liver Injury - BSG

   www.bsg.org.uk › web-education › drug-induced-liver

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   Idiosyncratic drug-induced liver injury (DILI) is an unpredictable type of liver injury following exposure to medication within the recommended dose which is distinctive from liver injury caused by drug overdosage, commonly caused by paracetamol overdose (POD).

3. www.uptodate.com › contents › drug-induced-liver-injuryDrug-induced liver injury - UpToDate

   www.uptodate.com › contents › drug-induced-liver-injury

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   Apr 14, 2023 · A high index of suspicion is often necessary to expeditiously establish the diagnosis. This topic will review the epidemiology, clinical manifestations, diagnosis, and management of drug-induced liver injury (DILI).

4. gut.bmj.com › content › 66/6/1154Drug-induced liver injury: recent advances in diagnosis and ...

   gut.bmj.com › content › 66/6/1154

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   Idiosyncratic drug-induced liver injury (IDILI) is a rare but potentially severe adverse drug reaction that should be considered in patients who develop laboratory criteria for liver injury secondary to the administration of a potentially hepatotoxic drug.

   • Author: Gerd A Kullak-Ublick, Raul J Andrade, Michael Merz, Peter End, Andreas Benesic, Alexander L Gerbes, ...

   • Publish Year: 2017

5. www.journal-of-hepatology.eu › article › S0168-8278EASL Clinical Practice Guidelines: Drug-induced liver injury

   www.journal-of-hepatology.eu › article › S0168-8278

   A meta-analysis of results from candidate gene studies investigating drug-metabolising enzyme (DME) polymorphisms on the risk of anti-TBC DILI showed a substantial variation in association between SNPs in N-acetyltransferase 2 (NAT2) and DILI.

   • Author: Raúl J. Andrade, Guruprasad P. Aithal, Einar S. Björnsson, Neil Kaplowitz, Gerd A. Kullak-Ublick, Do...

   • Publish Year: 2019

6. www.ncbi.nlm.nih.gov › books › NBK557535Drug-Induced Hepatotoxicity - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK557535

   Sep 10, 2024 · The pathogenesis of DILI can be divided into 2 mechanisms: intrinsic and idiosyncratic. The intrinsic mechanism is both predictable and reproducible from drugs that are known to cause liver injury in a dose-dependent manner with a short latency period.

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   What is drug-induced liver injury (DILI)?

   • This topic will review the epidemiology, clinical manifestations, diagnosis, and management of drug-induced liver injury (DILI). The metabolism of drugs by the liver, the mechanisms by which drugs might injure the liver, and the use of medications in patients with liver disease are discussed separately.

   Drug-induced liver injury - UpToDate

   www.uptodate.com/contents/drug-induced-liver-injury

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   How is Dili classified?

   • DILI can be classified based on clinical presentation (hepatocellular, cholestatic, or mixed), mechanism of hepatotoxicity, or histological appearance from a liver biopsy. The true incidence is difficult to estimate, yet it has become the leading cause of acute liver failure (ALF) in the United States.

   Drug-Induced Hepatotoxicity - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK557535/

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   What does Dili stand for?

   • DILI, drug-induced liver injury; ER, endoplasmic reticulum; GSH, glutathione; ROS, reactive oxygen species. Idiosyncratic DILI is a serious matter with consequences on various levels, including individual patient health, pharmaceutical regulatory decisions and drug development schemes.

   EASL Clinical Practice Guidelines: Drug-induced liver injury

   www.journal-of-hepatology.eu/article/S0168-8278(19)30129-1/fulltext

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   What is the pathogenesis of Dili?

   • The pathogenesis of DILI can be divided into 2 mechanisms: intrinsic and idiosyncratic. The intrinsic mechanism is both predictable and reproducible from drugs that are known to cause liver injury in a dose-dependent manner with a short latency period.

   Drug-Induced Hepatotoxicity - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov/books/NBK557535/

   See all results for this question

   Does Dili cause liver damage?

   • In a study of 598 prospectively identified DILI cases by the US DILIN group, 18.9% of patients had signs of persistent liver damage, with chronic DILI defined as elevations in liver tests, histological or radiological evidence of ongoing liver injury at 6 months after enrolment.

   EASL Clinical Practice Guidelines: Drug-induced liver injury

   www.journal-of-hepatology.eu/article/S0168-8278(19)30129-1/fulltext

   See all results for this question

   What is idiosyncratic drug-induced liver injury (DILI)?

   • Idiosyncratic drug-induced liver injury (DILI) is an unpredictable type of liver injury following exposure to medication within the recommended dose which is distinctive from liver injury caused by drug overdosage, commonly caused by paracetamol overdose (POD).

   Drug-induced Liver Injury - BSG

   www.bsg.org.uk/web-education/drug-induced-liver-injury

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8. www.ncbi.nlm.nih.gov › pmc › articlesDrug-induced liver injury - PMC - National Center for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   At a regulatory level, drug-induced liver injury (DILI) is the commonest reason for withdrawing drugs from the market and/or issuing warnings and modification of use. DILI is classified as either predictable or unpredictable (idiosyncratic).