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- A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
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Sep 23, 2021 · Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
- Peaks and troughs are the highest and lowest concentrations of a medication in an individual’s body. They are used to determine dosing intervals, o...
- The time to take peak levels depends on the route of administration. The peak level is taken about 15 to 30 minutes after intravenous injections or...
- Peaks and troughs are the highest and lowest concentrations, respectively, of a medication in an individual’s body. They are used to determine dosi...
A trough level is drawn when the drug is at its lowest in the bloodstream, right before the next scheduled dose is given. Medications have a predicted reference range of normal values for peak and trough levels.
- 2023
In medicine and pharmacology, a trough level or trough concentration (C trough) is the concentration reached by a drug immediately before the next dose is administered, [1] [2] often used in therapeutic drug monitoring.
Trough concentrations can be measured to determine drug accumulation and to reduce the risk of toxicity. Trough samples must be interpreted in the context of the time after the dose when the sample was drawn.
The maximum or “peak” concentration (Cmax) of a drug observed after its administration; the minimum or “trough” concentration (Cmin) of a drug observed after its administration and just prior to the administration of a subsequent dose.
The trough level is the lowest concentration of drug before the next dose. From: Contemporary Practice in Clinical Chemistry (Fourth Edition), 2020
Target range: trough >10 mg/L (total drug) or peak concentration >20 mg/L. patients with serious infections require higher concentrations; monitor the trough concentration and increase the teicoplanin dose if the concentration falls <20 mg/L. toxicity is unusual at trough concentrations <50 mg/L.
