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- Dictionarymast cell
noun
- 1. a cell filled with basophil granules, found in numbers in connective tissue and releasing histamine and other substances during inflammatory and allergic reactions.
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A mast cell (also known as a mastocyte or a labrocyte[ 1 ]) is a resident cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems.
Mast cells are tissue-resident cells that can release inflammatory mediators in response to various stimuli. Learn about their development, location, role in host defence and allergic reactions, and how they are activated by different antigens.
May 16, 2024 · Mast cells are a part of your immune system. They’re made in your bone marrow, then move through your bloodstream into your tissues. The mature mast cells live in tissues throughout your body to help protect you from hazards around you. They can help fight infections and regulate your organs. When your mast cells are overprotective, you may ...
15 Chymase is also present in substantial amounts in particular sub-populations of mast cells and the relative abundance of tryptase and chymase in human mast cells has been employed to define particular mast cell phenotypes. 16 These granule-associated proteases are complexed to proteoglycans. One example is heparin which helps to stabilize ...
- Alasdair M. Gilfillan, Sarah J. Austin, Dean D. Metcalfe
- 2011
Jan 6, 2016 · Introduction. Mast cells are important cells of the immune system and are of the hematopoietic lineage. Mast cells are originated from pluripotent progenitor cells of the bone marrow, and mature under the influence of the c-kit ligand and stem cell factor in the presence of other distinct growth factors provided by the microenvironment of the tissue where they are destined to reside.
- Melissa Krystel-Whittemore, Kottarappat N. Dileepan, John G. Wood
- 10.3389/fimmu.2015.00620
- 2016
- Front Immunol. 2015; 6: 620.
May 1, 2023 · Mast cells are oval or irregularly shaped cells. Under light microscopy, a dense granular cytoplasm is seen, often obscuring the nucleus and other organelles. When it can be visualized, the nucleus is central, and the cell is mononuclear. Mast cells are found throughout the body in loose connective tissue.
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Mar 19, 2024 · Mast cell tumors: Mast cell sarcoma is a rare, aggressive neoplasm composed of cytologically malignant, highly atypical, mast cells. This presents as a localized, destructive growth. However, the pathological features of this entity are not well characterized. 11 Mast cell leukemia is a very aggressive form of the disease and, as the name suggests, large numbers of mast cells are found in the ...
