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What are idiosyncratic reactions?
How are idiosyncratic drug reactions different from pharmacological effects?
What is the delay between idiosyncratic drug reactions?
What are idiosyncratic adverse drug reactions?
The term idiosyncratic drug reaction (IDR) has been used in various ways and has no clear definition, but the term is used in this review to designate an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug.
- Fig. 4
The quinone methide covalently binds in the liver,...
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Idiosyncratic drug reactions are a significant cause of...
- PMC Free Article
A number of immune-mediated or idiosyncratic drug reactions...
- Pathogenesis, Diagnosis and Management
PATHOGENESIS. The etiology of drug-induced immune...
- Granulysin Activates Antigen-Presenting Cells Through TLR4 and Acts as an Immune Alarmin
The proliferative response of T cells was examined by...
- Risk Factors for Idiosyncratic Drug-Induced Liver Injury
Age. Age is a risk factor for DILI, but only from specific...
- Cytochrome B5 and Nadh Cytochrome B5 Reductase
Objectives. NADH cytochrome b 5 reductase (b5R) and...
- T-cell Involvement in Drug-Induced Acute Generalized Exanthematous Pustulosis
This heterogeneity in the TCR Vβ of TCCs suggests the lack...
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Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. This is not to be mistaken with idiopathic, which implies that the cause is not known.
Idiosyncratic. Dose-related adverse drug reactions represent an exaggeration of the drug's therapeutic effects. For example, a person taking a medication to reduce high blood pressure may feel dizzy or light-headed if the medication reduces blood pressure too much.
- Pharmacological Definition of Idiosyncrasy
- Pathophysiology of Idiosyncratic Drug Reactions
- Classical Examples of Drug-Induced Idiosyncratic Reactions
The definition from Textbook of Pharmacologyby Seth is: That's probably as good as it gets. It is impossible to give a clear official definition for exam purposes because the term, as Uetrecht and Nasibitt put it, "has been used in various ways and has no clear definition". These authors decided to describe it as That is quite different from Goodma...
Idiosyncratic reactions are generally thought to be immune-mediated. There is no agreement on their precise mechanism, and there are many exceptions to contradict every hypothesis. In summary: 1. Either the drug itself, or a reactive metabolite, binds to a protein 2. That protein undergoes a chemical and morphological change, breaking self-toleranc...
There is the distinct possibility that some cruel viva scenario will call for the sweating exam candidate to produce a list of idiosyncratic drug reactions as examples. A solid offering from the literature is hard to find. Here is a short list which was generated by combing through the article by Knowles et al (2000) and Park et al (1992)
Idiosyncrasy is an imprecise term that has been defined as a genetically determined abnormal response to a drug, but not all idiosyncratic reactions have a pharmacogenetic cause. The term may become obsolete as specific mechanisms of ADRs become known.
Nov 1, 2003 · Idiosyncratic reactions are qualitatively aberrant reactions that cannot be explained by the known pharmacologic action of the drug and occur only in a small percent of the population. A...
Idiosyncratic drug reactions are adverse drug reactions that do not occur in most patients at any dose and do not involve the known pharmacological properties of the drug.
