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Jul 15, 2019 · Diagnosis. Erythema multiforme is diagnosed clinically, based on the patient's history and physical examination. It is important to ask about recent symptoms of infection (e.g.,...
- Lamoreux, Et AL
Erythema multiforme is an acute, self-limited, and sometimes...
- Letters to The Editor
In Reply: We thank Drs. Irwin and Crawford-Faucher for...
- Lamoreux, Et AL
Dec 2, 2022 · Erythromelalgia (EM) is a rare debilitating disorder characterized by episodes of burning pain associated with red, hot feet and occasionally hands (Figure). Feet and hands may be swollen during symptoms, although edema is not universally present or reported.
Jan 28, 2021 · Erythema multiforme is a mild, self-limiting, potentially recurring mucocutaneous inflammatory condition. Characterised by target lesions that resemble a bull's eye. These usually erupt over 24 to 48 hours and last for 1 to 2 weeks. Typically presents in a symmetrical distribution of lesions over...
Sep 1, 2021 · A Mayo Clinic series of 48 patients diagnosed with recurrent EM suggested that HSV infection was the most common cause; however, over 60% of patients were determined to have idiopathic recurrent EM [1,3].
- Alexa Soares, Olayemi Sokumbi
- 10.3390/medicina57090921
- 2021
- Medicina (Kaunas). 2021 Sep; 57(9): 921.
- What Is Erythema Multiforme?
- Who Gets Erythema Multiforme?
- What Causes Erythema Multiforme?
- What Are The Clinical Features of Erythema Multiforme?
- How Do Clinical Features Vary in Differing Types of Skin?
- What Are The Complications of Erythema Multiforme?
- How Is Erythema Multiforme Diagnosed?
- What Is The Differential Diagnosis For Erythema Multiforme?
- What Is The Treatment For Erythema Multiforme?
- What Is The Outcome For Erythema Multiforme?
Erythema multiforme is an immune-mediated, typically self-limiting, mucocutaneous condition characterised by ‘target’ lesions. Significant mucosal involvement distinguishes erythema multiforme major from multiforme minor. Episodes can be isolated, recurrent, or persistent. In most cases, erythema multiforme is precipitated by herpes simplex virus (...
Erythema multiforme affects less than 1% of the population. It is most common in young adults (aged 20–40 years) with a modest predominance in males. There is no association with race. There appears to be a genetic predisposition in people carrying the HLA-DQB1*0301 allele, which shares an even stronger association with herpes-related erythema mult...
Infection precipitates 90% of cases, with HSV type 1 being the predominant cause. Other infectious triggers include: 1. HSV type 2 2. Cytomegalovirus 3. Epstein-Barr virus 4. Influenza virus 5. Vulvovaginal candidiasis 6. SARS-CoV-2 7. Orf. Mycoplasma pneumoniae infection is often listed as a trigger of erythema multiforme, however mucocutaneous ma...
Many patients report prodromal symptoms including fatigue, malaise, myalgia, or fever. These likely represent the course of precipitating illness rather than true prodrome.
No documented variation across skin type.No known associations with race.Cutaneous lesions resolve without scarring, though hyperpigmentation may persistfor several months. Ocular involvement can lead to more serious complications including: 1. Keratitis 2. Conjunctival scarring 3. Uveitis 4. Permanent visual impairment.
Diagnosis is often made based on history and clinical examination. Where there is doubt about the diagnosis, consider: 1. Complete blood examination 2. Liver functions tests 3. ESR 4. Serologicaltesting for infectious causes 5. Chest x-ray. Skin biopsy with histopathology and direct immunofluorescence can be non-specific but helps to distinguish er...
Treatment is often not needed as episodes are typically self-limiting with no ongoing complications. However, ocular involvement should always prompt ophthalmology referral given the risk for more serious sequelae. Treatment of symptomatic mild cases: 1. Itch — oral antihistamines and/or topical steroidsfor itch or discomfort associated with cutane...
Erythema multiforme is self-limiting with little to no ongoing complication in most patients. Recurrent or persistent disease comes with additional treatment challenges, but remission can be achieved.
Erythema multiforme (EM) is an acute, immune-mediated, mucocutaneous condition that is most commonly caused by herpes simplex virus (HSV) infection and the use of certain medications. 1,2 It is characterized by acrally distributed, distinct targetoid lesions with concentric color variation, sometimes accompanied by oral, genital, or ocular ...
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What causes recurrent erythema multiforme (EM)?
Apr 25, 2023 · Erythema multiforme (EM) is an acute, immune-mediated condition characterized by the appearance of distinctive target-like lesions on the skin (picture 1A-H). These lesions are often accompanied by erosions or bullae involving the oral, genital, and/or ocular mucosae (picture 2A-C).
