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Daniele NATALINI, Consultant | Cited by 629 | of Policlinico Universitario Agostino Gemelli, Rome | Read 20 publications | Contact Daniele NATALINI
- Pathophysiology and Rationale
- Clinical Trials on Targeted Temperature Management
- Recent Systematic Reviews
- Ilcor and Erc/Esicm Recommendations
- Points For Discussion and Knowledge Gaps
The human brain is very susceptible to HIBI—consciousness is lost between 4 and 10 s after the arrest of cerebral blood flow and the electroencephalogram becomes isoelectric 10–30 s after circulatory arrest. Irreversible damage to the neurons starts immediately upon cessation of cerebral perfusion because of the lack of inherent energy stores, and ...
Two pilot trials published in 1997 and 2000 showed the feasibility of cooling post-cardiac arrest patients in the emergency department [12, 13]. In 2002, two clinical trials, one randomized and one pseudorandomized , documented improved outcomes with mild hypothermia in patients initially comatose after OHCA with an initial shockable rhythm. In th...
After the publication of the TTM-2 trial, the Advanced Life Support (ALS) Task Force of the International Liaison Committee on Resuscitation (ILCOR) commissioned a new systematic review and meta-analysis of trials on temperature management in adult patients with HIBI after resuscitation from OHCA or IHCA from all rhythms . The questions addressed b...
Based on the results of the ILCOR-commissioned systematic review, the ILCOR ALS Task Force posted online its recommendations (Table 1) [36, 37]. The most significant change compared with previous recommendations was that hypothermia was no longer recommended for the treatment of comatose cardiac arrest survivors. Instead, the Task Force suggested a...
Despite insufficient evidence to recommend for or against temperature control at 32–36.8 °C after cardiac arrest, most members of the ILCOR ALS Task Force and the ERC-ESICM panel were keen to leave open this option in some patient categories according to local protocols. One reason was that most patients included in the evidence reviews had been in...
- Claudio Sandroni
Fondazione Policlinico Universitario A. Gemelli IRCCS - Cited by 677 - critical care medicine - anaesthesia
Oct 7, 2019 · Daniele Natalini 1 , Domenico L Grieco 1 , Maria Teresa Santantonio 1 , Lucrezia Mincione 2 , Flavia Toni 1 , Gian Marco Anzellotti 1 , Davide Eleuteri 1 , Pierluigi Di Giannatale 2 , Massimo Antonelli 1 , Salvatore Maurizio Maggiore 3
- Daniele Natalini, Domenico L. Grieco, Maria Teresa Santantonio, Lucrezia Mincione, Flavia Toni, Gian...
- 2019
lysis to synthesize the most recent evidence to determine whether MAC or SAS is safer and more effective for AC. We included randomized controlled trials and observational studies that explored the incidence of AC failure, duration of surgery, and hospital length of stay in adult patients undergoing AC. Eighteen studies were included in the final analysis. MAC was associated with a lower risk ...
Mar 6, 2014 · Daniele Natalini, Domenico L. Grieco, Massimo Antonelli, Advantages and drawbacks of helmet noninvasive support in acute respiratory failure, Expert Review of Respiratory Medicine, ...
Oct 7, 2019 · Daniele Natalini, Domenico L. Grieco, Maria Teresa Santantonio, Flavia Toni, Gian Marco Anzellotti, Davide Eleuteri & Massimo Antonelli Department of Medical, Oral and Biotechnological Sciences, School of Medicine and Health Sciences, Section of Anesthesia Analgesia, Perioperative and Intensive Care, SS.
