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Daniela MERLO, Laboratory Head | Cited by 2,399 | of Istituto Superiore di Sanità, Rome (ISS) | Read 65 publications | Contact Daniela MERLO
The formation of double strand breaks (DSBs), the most lethal form of DNA damage, may be a physiological process that modifies chromatin organization and gene expression involved in information processing, learning, and memory and may be caused by normal brain activity.
We found that H 2 O 2 treatment of PC12 cells induces an increase in DNA-PK protein complex levels, along with an elevation of DNA damage, measured both by the formation of γΗ2ΑX foci, detected by immunofluorescence, and γH2AX levels detected by western blot analysis.
- Alessio Cardinale, Serena Saladini, Leonardo Lupacchini, Irene Ruspantini, Chiara De Dominicis, Marc...
- 2021
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Mar 5, 2021 · Daniela Merlo. 4669 Accesses. 11 Citations. 2 Altmetric. Explore all metrics. Abstract. Translating successful preclinical research in neurodegenerative diseases into clinical practice has been difficult. The preclinical disease models used for testing new drugs not always appear predictive of the effects of the agents in the human disease state.
- Cristiana Mollinari, Daniela Merlo
- 2021
Mar 5, 2021 · Abstract. Translating successful preclinical research in neurodegenerative diseases into clinical practice has been difficult. The preclinical disease models used for testing new drugs not always appear predictive of the effects of the agents in the human disease state.
In this Commentary we present and discuss strength and weakness of several strategies for the direct cellular reprogramming from somatic cells to generate human brain cells which maintain age-related features.
