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1. www.nejm.org › doi › fullAngiotensin Receptor–Neprilysin Inhibition in Acute ...

   www.nejm.org › doi › full

   Nov 10, 2021 · We conducted the Prospective ARNI versus ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events after Myocardial Infarction (PARADISE-MI), an international, multicenter...

   • Author: Marc A. Pfeffer, Brian Claggett, Eldrin F. Lewis, Christopher B. Granger, Lars Køber, Aldo P. Maggio...

   • Publish Year: 2021

2. www.ahajournals.org › doi › absImpact of Sacubitril/Valsartan Compared With Ramipril on ...

   www.ahajournals.org › doi › abs

   Sep 9, 2022 · The PARADISE-MI Echo Study (Prospective ARNI Versus ACE Inhibitor Trial to Determine Superiority in Reducing Heart Failure Events After Myocardial Infarction) tested the effect of sacubitril/valsartan compared with ramipril on LV function and adverse remodeling after high risk-AMI.

3. www.jacc.org › doi › 10Angiotensin Receptor-Neprilysin Inhibition in Patients With ...

   www.jacc.org › doi › 10

   The PARADISE-MI (Prospective ARNI versus ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction) trial enrolled patients with AMI complicated by left ventricular dysfunction and/or pulmonary congestion and at least 1 risk-enhancing factor.

4. www.sciencedirect.com › science › articleAcute Decompensated Heart Failure in the Setting of Acute ...

   www.sciencedirect.com › science › article

   Jun 1, 2022 · Recent neutral findings for use of ARNI after MI underscore the need for dedicated trials exploring the efficacy of new GDMT therapies in the post-MI population. •. Future work is needed to improve implementation of existing therapies, and to identify new therapies for this high-risk group. Abstract.

5. www.sciencedirect.com › science › articleTreatment strategies of acute myocardial infarction: updates ...

   www.sciencedirect.com › science › article

   Feb 1, 2023 · The randomized PARADISE-MI trial (n = 5661) tested whether treatment with angiotensin receptor-neprilysin inhibitor (ARNI) (i.e. sacubitril-valsartan) would result in a lower incidence of cardiovascular death and heart failure than ACE inhibitor, when initiated shortly after acute MI in patients with a reduced EF and/or transient pulmonary ...

6. www.ahajournals.org › doi › 10Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on ...

   www.ahajournals.org › doi › 10

   Jun 26, 2019 · We conducted a meta‐analysis to compare the effects of ARNI versus angiotensin‐converting enzyme inhibitors or angiotensin receptor blockers on CRR indices. We searched databases for studies published between 2010 and 2019 that reported CRR indices following ARNI administration.

7. People also ask

   Does Arni help HFpEF patients?

   • The current meta‐analysis included only 1 HFpEF trial [PARAMOUNT study (Prospective Comparison of ARNI with ARB on Management Of Heart Failure with Preserved Ejection Fraction)], and no conclusions could therefore be drawn regarding the benefits of ARNI in HFpEF patients.

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

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   Does Arni improve functional capacity in patients with heart failure?

   • Twenty studies enrolling 10 175 patients were included. ARNI improved functional capacity in patients with heart failure (HF) and a reduced ejection fraction (EF), including increasing New York Heart Association functional class (MD −0.79, 95% CI −0.86, −0.71) and 6‐minute walking distance (MD 27.62 m, 95% CI 15.76, 39.48).

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

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   What are the shortterm benefits of Arni on CRR?

   • The short‐term benefits of ARNI on CRR may relate to its long‐term effects on functional capacity and cardiovascular outcomes. It may be beneficial to administer ARNI to eligible patients as early as possible.

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

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   Does Arni outperform angiotensin converting enzyme inhibitors?

   • ARNI outperformed angiotensin‐converting enzyme inhibitors/angiotensin receptor blockers in terms of CRR indices, with striking changes in left ventricular EF, diameter, and volume.

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

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   Does Arni affect CRR indices and functional capacity?

   • Subgroup analysis according to follow‐up period showed striking effects of ARNI on CRR indices and functional capacity at 3 months, increasing over time. This suggested that ARNI had a rapid therapeutic effect within 3 months, but the maximal treatment effects were uncertain.

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

   See all results for this question

   Does Arni improve left ventricular mass index?

   • However, there were no significant improvements in indices except left ventricular mass index (MD −3.25 g/m 2, 95% CI −3.78, −2.72) and left atrial volume (MD −7.20 mL, 95% CI −14.11, −0.29) in HF patients with preserved EF treated with ARNI.

   Effects of the Angiotensin‐Receptor Neprilysin Inhibitor on Cardiac

   www.ahajournals.org/doi/10.1161/JAHA.119.012272

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8. pubmed.ncbi.nlm.nih.gov › 36321459The Effects of Angiotensin Receptor-Neprilysin Inhibition on ...

   pubmed.ncbi.nlm.nih.gov › 36321459

   Nov 2, 2022 · Methods: We conducted a prespecified analysis of the PARADISE-MI trial (Prospective ARNI vs ACE Inhibitors Trial to Determine Superiority in Reducing Heart Failure Events After MI), which compared sacubitril/valsartan (97/103 mg twice daily) with ramipril (5 mg twice daily) for reducing heart failure events after myocardial infarction in 5661 ...