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      • Statins may not be suitable if you have severe liver disease, or blood tests suggest that your liver may not be working properly. Statins can affect your liver, and this is more likely to cause serious problems if you already have a severely damaged liver.
      www.nhsinform.scot/tests-and-treatments/medicines-and-medical-aids/types-of-medicine/statins/
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  2. Statins should not be taken if you have liver disease or if blood tests suggest that your liver may not be working properly. This is because statins can affect your liver, and this is more likely to cause serious problems if you already have a damaged liver.

    • Uses

      Statins may be recommended if you have cardiovascular...

    • Side Effects

      Rare side effects of statins include: muscle weakness...

  3. The study included 168 patients with liver injury caused by statins. Treatment with bicyclol compared with polyene phosphatidylcholine (control) resulted in lower ALT levels after 4 weeks of therapy and high rates of transaminase normalization.

    • Lindsay Meurer, Stanley Martin Cohen
    • 2020
    • Introduction
    • Why Have I Been Offered Statins?
    • Taking Statins
    • Cautions and Interactions
    • Side Effects of Statins
    • Alternatives to Statins

    Statins are a group of medicines that can help lower the level of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol is often referred to as “bad cholesterol”, and statins reduce the production of it inside the liver.

    Having a high level of LDL cholesterol is potentially dangerous, as it can lead to a hardening and narrowing of the arteries (atherosclerosis) and cardiovascular disease (CVD). CVD is a general term that describes a disease of the heart or blood vessels. It’s the most common cause of death in the UK. The main types of CVD are: 1. coronary heart dis...

    Statins come as tablets that are taken once a day. The tablets should normally be taken at the same time each day – most people take them just before going to bed. In most cases, treatment with statins continues for life, as stopping the medication causes your cholesterol to return to a high level within a few weeks. If you ever forget to take your...

    Statins can sometimes interact with other medicines, increasing the risk of unpleasant side effects, such as muscle damage. Some types of statin can also interact with grapefruit juice. It’s very important to read the information leaflet that comes with your medication, to check if there are any interactions you should be aware of. If in doubt, con...

    Many people who take statins experience no or very few side effects. Others experience some troublesome – but usually minor – side effects, such as an upset stomach, headacheor feeling sick. Your doctor should discuss the risks and benefits of taking statins if they’re offered to you. Cases that involve more serious side effects, such as kidney fai...

    If you’re at risk of developing CVD in the near future, your doctor will usually recommend lifestyle measures to reduce this risk before they suggest that you take statins. Lifestyle measures that can reduce your cholesterol level and CVD risk include: 1. eating a healthy, balanced diet 2. exercising regularly 3. maintaining a healthy weight 4. lim...

  4. Nov 8, 2016 · In summary, clinically important liver injury from statins is very rare, but use of statins can be associated with liver injury and sometimes severe hepatotoxicity. Among statins, only atorvastatin and simvastatin induced liver injury has been associated with fatal outcome.

    • Einar S. Björnsson
    • 2017
  5. Jan 17, 2019 · There is now overwhelming evidence to support reducing LDL-c (low-density lipoprotein cholesterol) to reduce atherosclerotic cardiovascular disease (CVD). 3 Statins are the most widely prescribed and evidence-based lipid-lowering drug in the world for lowering LDL-c and reducing cardiovascular morbidity and mortality, both in primary and seconda...

  6. Mar 15, 2011 · An expert consensus panel of hepatologists convened by the National Lipid Association concluded that chronic liver disease is not a contraindication to statin use.

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