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Serotonergic Agents. The serotonin [5-hydroxytryptamine (5-HT)] system has been studied extensively in the etiology of anxiety and anxiety disorders, and the primary first-line pharmacotherapeutic agents for anxiety are serotonergic, including SSRIs, SNRIs, and azapirones like buspirone.
- The efficacy, safety, and adverse events of azapirones in ...
Confidence in estimates was high/moderate vs. placebo,...
- The efficacy, safety, and adverse events of azapirones in ...
Generalized anxiety disorder is one of the most common anxiety disorders and can be costly if unrecognized or left untreated. Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from GAD. This systematic review evaluates the effectiveness of azapirones compared to other treatments.
Nov 1, 2023 · The present systematic review (SR) and meta-analysis aim to investigate the efficacy and tolerability of azapirones across anxiety disorders, both versus placebo and other active pharmacological interventions, and to assess their usefulness as a tolerable alternative treatment for anxiety.
Jun 17, 2021 · In this review, the author examines the evidence for psychopharmacologic treatments among adults for generalized anxiety disorder, panic disorder, and social anxiety disorder derived from clinical trials. For each disorder, major categories of drugs are reviewed, and then the evidence-based medications in each category are discussed. The author reviews key safety and tolerability ...
Confidence in estimates was high/moderate vs. placebo, moderate/low vs. benzodiazepine, very-low vs. SRIs. Azapirones failed to outperform the placebo in panic and social anxiety disorders. Azapirones overlapped placebo and SRIs in drop-out rates, while they showed higher treatment discontinuation rates than benzodiazepines (RR=1.33, 95%C.I.[1. ...
IN THE TREATMENT OF ANXIETY DISORDERS Benzodiazepines and Azapirones Standard treatment for anxiety has included treatment with benzodiazepines and azapirones. The benzodiaze-pines are effective, at least in the short term, in treating anxiety and panic, with a more rapid resolution of the so-matic manifestations of anxiety.11,12 However, with the
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Aug 4, 2023 · It is often associated with other psychiatric disorders, such as drug dependence, major depression, bipolar disorder, social phobia, specific phobia and generalised anxiety disorder. Azapirones ...