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1. pmc.ncbi.nlm.nih.gov › articles › PMC7786299Pharmacotherapy of Anxiety Disorders: Current and Emerging ...

   pmc.ncbi.nlm.nih.gov › articles › PMC7786299

   Serotonergic Agents. The serotonin [5-hydroxytryptamine (5-HT)] system has been studied extensively in the etiology of anxiety and anxiety disorders, and the primary first-line pharmacotherapeutic agents for anxiety are serotonergic, including SSRIs, SNRIs, and azapirones like buspirone.

   • The efficacy, safety, and adverse events of azapirones in ...

     Confidence in estimates was high/moderate vs. placebo,...

2. www.cochrane.org › CD006115Azapirones for generalized anxiety disorder (GAD) - Cochrane

   www.cochrane.org › CD006115

   • Cached

   Generalized anxiety disorder is one of the most common anxiety disorders and can be costly if unrecognized or left untreated. Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from GAD. This systematic review evaluates the effectiveness of azapirones compared to other treatments.

3. www.sciencedirect.com › science › articleThe efficacy, safety, and adverse events of azapirones in ...

   www.sciencedirect.com › science › article

   Nov 1, 2023 · The present systematic review (SR) and meta-analysis aim to investigate the efficacy and tolerability of azapirones across anxiety disorders, both versus placebo and other active pharmacological interventions, and to assess their usefulness as a tolerable alternative treatment for anxiety.

4. psychiatryonline.org › doi › 10Pharmacotherapy for Anxiety Disorders: From First-Line ...

   psychiatryonline.org › doi › 10

   Jun 17, 2021 · In this review, the author examines the evidence for psychopharmacologic treatments among adults for generalized anxiety disorder, panic disorder, and social anxiety disorder derived from clinical trials. For each disorder, major categories of drugs are reviewed, and then the evidence-based medications in each category are discussed. The author reviews key safety and tolerability ...

5. pubmed.ncbi.nlm.nih.gov › 37544075The efficacy, safety, and adverse events of azapirones in ...

   pubmed.ncbi.nlm.nih.gov › 37544075

   Confidence in estimates was high/moderate vs. placebo, moderate/low vs. benzodiazepine, very-low vs. SRIs. Azapirones failed to outperform the placebo in panic and social anxiety disorders. Azapirones overlapped placebo and SRIs in drop-out rates, while they showed higher treatment discontinuation rates than benzodiazepines (RR=1.33, 95%C.I.[1. ...

6. www.psychiatrist.com › wp-content › uploadsOverview of Antidepressants Currently Used to Treat Anxiety ...

   www.psychiatrist.com › wp-content › uploads

   IN THE TREATMENT OF ANXIETY DISORDERS Benzodiazepines and Azapirones Standard treatment for anxiety has included treatment with benzodiazepines and azapirones. The benzodiaze-pines are effective, at least in the short term, in treating anxiety and panic, with a more rapid resolution of the so-matic manifestations of anxiety.11,12 However, with the

7. People also ask

   Are azapirones effective for generalized anxiety disorder?

   • Generalized anxiety disorder is one of the most common anxiety disorders and can be costly if unrecognized or left untreated. Azapirones are a group of drugs that work at the 5-HT1A receptor and are used to treat patients suffering from GAD. This systematic review evaluates the effectiveness of azapirones compared to other treatments.

   Azapirones for generalized anxiety disorder (GAD) | Cochrane

   www.cochrane.org/CD006115/DEPRESSN_azapirones-for-generalized-anxiety-disorder-gad

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   Are azapirones useful in the treatment of Gad?

   • Azapirones appeared to be useful in the treatment of GAD, particularly for those participants who had not been on a benzodiazepine. Azapirones may not be superior to benzodiazepines and do not appear as acceptable as benzodiazepines. Side effects appeared mild and non serious in the azapirone treated group.

   Azapirones for generalized anxiety disorder (GAD) | Cochrane

   www.cochrane.org/CD006115/DEPRESSN_azapirones-for-generalized-anxiety-disorder-gad

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   Are phenelzine and tranylcypromine effective for anxiety disorders?

   • Presumably because they increase 5-HT transmission in addition to DA and NE, only the nonselective MAOIs phenelzine and tranylcypromine have demonstrated significant efficacy for anxiety disorders, specifically panic disorder and social anxiety disorder (69 – 72).

   Pharmacotherapy for Anxiety Disorders: From First-Line

   psychiatryonline.org/doi/10.1176/appi.focus.20200048

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   Are high-potency clonazepam and alprazolam a good first-line treatment for panic disorder?

   • Before the establishment of SRIs as first-line treatment for panic disorder, the high-potency BZDs (HPBs) clonazepam and alprazolam were preferred treatments because of their rapid onset of effect, tolerability, and sustained antipanic efficacy over time. For reasons already discussed, these medications have fallen out of favor.

   Pharmacotherapy for Anxiety Disorders: From First-Line

   psychiatryonline.org/doi/10.1176/appi.focus.20200048

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   Can nefazodone be used to treat panic disorder?

   • Bupropion has been studied with mixed results (85). Nefazodone has multiple open trials supportive of efficacy for panic disorder at doses between 200 and 600 mg daily (86, 87).

   Pharmacotherapy for Anxiety Disorders: From First-Line

   psychiatryonline.org/doi/10.1176/appi.focus.20200048

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   What SSRIs are used for panic disorder?

   • As in generalized anxiety disorder, first-line (and second- and sometimes third-line) pharmacotherapy for panic disorder uses SRIs. The specific SSRIs that have FDA approval for panic disorder include fluoxetine, sertraline, and paroxetine (regular and controlled release). Venlafaxine XR is the sole SNRI with an FDA indication for panic disorder.

   Pharmacotherapy for Anxiety Disorders: From First-Line

   psychiatryonline.org/doi/10.1176/appi.focus.20200048

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8. www.researchgate.net › publication › 372964268_TheThe efficacy, safety, and adverse events of azapirones in ...

   www.researchgate.net › publication › 372964268_The

   Aug 4, 2023 · It is often associated with other psychiatric disorders, such as drug dependence, major depression, bipolar disorder, social phobia, specific phobia and generalised anxiety disorder. Azapirones ...