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Side effects. Side effects of azapirones may include dizziness, headaches, restlessness, nausea, and diarrhea. [4][22] Azapirones have more tolerable adverse effects than many other available anxiolytics, such as benzodiazepines or SSRIs. Unlike benzodiazepines, azapirones lack abuse potential and are not addictive, do not cause cognitive ...
Jul 31, 2017 · To compare individual active drugs (antidepressants, benzodiazepines and azapirones) and placebo in terms of efficacy and acceptability in the acute treatment of panic disorder, with or without agoraphobia.
Jul 13, 2022 · buspirone. tricyclic antidepressants. propranolol. pregabalin. hydroxyzine pamoate. Note that not all of the medications listed above are first-line for all anxiety disorders, and some are only ...
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May 15, 1996 · Substances. Anti-Anxiety Agents. Benzodiazepines. Buspirone. The azapirones are a relatively new class of psychotherapeutic drugs with both anxiolytic and antidepressant properties and a favorable benefit-to-risk ratio. They represent a significant advance in psychotherapeutic drug development. Buspirone, the only azapirone currently in ...
Nov 1, 2023 · Confidence in estimates was high/moderate vs. placebo, moderate/low vs. benzodiazepine, very-low vs. SRIs. Azapirones failed to outperform the placebo in panic and social anxiety disorders. Azapirones overlapped placebo and SRIs in drop-out rates, while they showed higher treatment discontinuation rates than benzodiazepines (RR=1.33, 95%C.I.[1.16, 1.53], k = 23, n = 2,768).
Jun 17, 2021 · A study comparing the low-potency benzo diazepam with alprazolam found similar antipanic efficacy . Interestingly, a 2019 Cochrane meta-analysis comparing BZDs with placebo for treatment of panic disorder slightly favored BZDs; however, the authors took care to point out the low quality of evidence and high risk of bias across most reviewed studies ( 55 ).
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The calculated number needed to treat for azapirones using the Clinical Global Impression scale was 4.4 (95% confidence interval (CI) 2.16 to 15.4). Azapirones may be less effective than benzodiazepines and we were unable to conclude if azapirones were superior to antidepressants, kava kava or psychotherapy. Azapirones appeared to be well ...
