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May 7, 2024 · Two control enzymes of the glycolytic pathway, hexokinase 2 (HK2) and phosphofructokinase muscle form (PFK1), were identified as bona fide ISGylation targets during infection. In an integrative approach complemented with enzymatic functional testing and structural modelling, we demonstrate that protein ISGylation obstructs the activity of HK2 and PFK1.
Antje Beling +49 30 450 528187. CharitéCentrum für Grundlagenmedizin (CC 2) Institut für Biochemie Charité Campus Mitte Charitéplatz 1, D-10117 Berlin
Antje Beling, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Biochemistry, Charitéplatz 1, 10117 Berlin, Germany; Deutsches Zentrum für Herz-Kreislauf-Forschung, partner site Berlin, Berlin, Germany.
Antje BELING, Group Leader | Cited by 1,794 | of Charité Universitätsmedizin Berlin, Berlin (Charité) | Read 73 publications | Contact Antje BELING
Ubiquitin-like protein ISG15 (interferon-stimulated gene 15) (ISG15) is a ubiquitin-like modifier induced during infections and involved in host defense mechanisms. Not surprisingly, many viruses encode deISGylating activities to antagonize its effect. Here we show that infection by Zika, SARS-CoV-2 and influenza viruses induce ISG15-modifying ...
- Deeksha Munnur, Qiwen Teo, Denzel Eggermont, Horace H Y Lee, Horace H Y Lee, Fabien Thery, Julian Ho...
- 2021
IMPRS-IDI Institute of Biochemistry Charité - Universitätsmedizin Berlin. Homepage. Institute
Since 2021: Tenured Professor (W2), for Biochemistry, , Charité – Universitätsmedizin Berlin: Since 2016: Scientist at German Centre for Cardiovascular Research, partner site Berlin
