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  1. Aravinda K. Chavalmane, PhD, Paolo Comeglio, PhD, Annamaria Morelli, PhD, Sandra Filippi, PhD, Benedetta Fibbi, MD, Linda Vignozzi, MD, Erica Sarchielli, PhD, Matilde ...

  2. Aug 1, 2010 · Aromatase and sex steroid receptors, including GPR30, were expressed in human bladder and mediates several biological functions. Both 17β-estradiol and G1 activated calcium transients and induced RhoA/ROCK signaling (cell migration, cytoskeleton remodeling and smooth muscle gene expression). RhoA/ROCK inhibitors blunted these effects.

    • Aravinda K. Chavalmane, Paolo Comeglio, Annamaria Morelli, Sandra Filippi, Benedetta Fibbi, Linda Vi...
    • 2010
  3. Aug 2, 2010 · Annamaria Morelli PhD. Sexual Medicine and Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence, Italy; Search for more papers by this author

    • Aravinda K. Chavalmane, Paolo Comeglio, Annamaria Morelli, Sandra Filippi, Benedetta Fibbi, Linda Vi...
    • 2010
  4. Jan 1, 2010 · PDE5 mRNA expression was higher in urethra and bladder than in prostate SMC. The antiproliferative effect of Sp-8-Br-PET-cGMPS was similar in all LUT SMC. In prostatic SMC, SNP and BAY 41-8543 show a dose-dependent antiproliferative effect that resulted marginally enhanced by vardenafil.

    • Benedetta Fibbi, Annamaria Morelli, Linda Vignozzi, Sandra Filippi, Aravinda Chavalmane, Giulia De V...
    • 2010
  5. Conflict of Interest: Linda Vignozzi, Annamaria Morelli, Sandra Filippi, Paolo Comeglio, Erica Sarchielli, Aravinda K. Chavalmane, Ravit Yehiely‐Cohen, Matilde Marchetta, and Gabriella B. Vannelli have nothing to declare. Mario Maggi is a scientific consultant for Bayer Schering Pharma AG, Germany, Eli‐Lilly Indianapolis, Indiana, USA.

    • Vignozzi, Linda
  6. Feb 1, 2009 · Results. Exposure to increasing concentrations of DHT after 24 hours significantly stimulated GnRH mRNA in FNC-B4. This effect was still present after prolonged exposure (48 hours). Similarly, treatment with leptin significantly induced GnRH mRNA after 24 hours, but not at 48 hours.

  7. Jun 13, 2013 · Phosphodiesterase type 5 inhibitors (PDE5i) are recognized as an effective treatment of BPH-related LUTS. One proposed mechanism of action of PDE5 is the inhibition of intraprostatic inflammation. In this study we investigate whether PDE5i could blunt inflammation in the human prostate.

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