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ALF in children has been defined by the Paediatric Acute Liver Failure Group (PALF) as a liver based coagulopathy with a PT ≥ 15 and INR ≥1.5, not corrected by Vitamin K in the presence of HE or PT ≥ 20 or INR ≥2, with the absence of an underlying chronic liver disease. 1.
- Self-assessment
A 12-year old male patient presented to his GP with a four...
- Self-assessment
Acute liver failure (ALF) in children, irrespective of cause, is a rapidly evolving catastrophic clinical condition that results in high mortality and morbidity without prompt identification and intervention.
Jul 5, 2024 · Acute liver failure in children: Etiology and evaluation; Approach to the child with metabolic acidosis; Causes of cholestasis in neonates and young infants; Children with early and life-threatening sepsis in resource-abundant settings: Rapid recognition and initial resuscitation (first hour)
Jun 10, 2024 · Pediatric acute liver failure (PALF) represents a medical emergency, characterized by the acute onset of hepatocellular damage manifesting as elevated hepatic transaminases and coagulopathies in a child without pre-existing liver disease.
May 1, 2021 · • In endemic countries, Dengue and yellow fever and in both endemic and non-endemic countries rubella and paramyxovirus, when suspected basing on clinical findings, should be tested in children presenting with ALF (Grade 1-B; 100%, 5 strongly agree, 5 agree).
- A. Di Giorgio, E. Bartolini, P.L. Calvo, M. Cananzi, F. Cirillo, C. Della Corte, C. Dionisi-Vici, G....
- 2021
Nov 5, 2020 · Pediatric acute liver failure (PALF) is a rapidly progressive syndrome in children that can lead to many devastating complications, such as renal and/or respiratory failure, hemodynamic instability, cerebral edema, sepsis, coagulopathy, and aplastic anemia [1, 2, 3, 4].
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Aug 2, 2022 · Medical management of children with acute liver failure (ALF) could avoid the need for liver transplantation. Extracorporeal therapies including continuous kidney replacement therapy and extracorporeal liver support systems are increasingly being applied in PALF.
