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  1. Antiheroes and reformed, semi-reformed, or occasionally reformed supervillains. [] The following is a list of Spider-Man adversaries who, at one point or another, have been reformed or semi-reformed, either temporarily or currently, or who are no longer primarily antagonists of Spider-Man.

    • Venom. 6,799 votes. With his menacing black suit and razor-sharp teeth, Venom strikes fear into the hearts of both heroes and villains alike. This symbiotic creature not only possesses incredible strength and agility but also has the ability to mimic Spider-Man's powers, making him a formidable adversary.
    • Green Goblin. 6,520 votes. The cackling laughter echoing through the night can only mean one thing - the Green Goblin is on the prowl! Norman Osborn's alter ego combines cunning intelligence with an arsenal of deadly weapons, including his infamous pumpkin bombs.
    • Doctor Octopus. 5,945 votes. With his mechanical tentacles extending from his back, Doctor Octopus is a scientific genius turned supervillain who poses a unique threat to Spider-Man.
    • Mysterio. 4,675 votes. Step right up and witness the illusions crafted by Mysterio, master of deception! Quentin Beck's expertise in special effects combined with his theatrical flair make him a captivating villain who always keeps audiences guessing.
    • Kai Young
    • Senior Staff Writer
    • Adrian Toomes, A.K.A. Vulture - Spider-Man: Homecoming (2017) Played by Michael Keaton. Cool tech-focused suit and real physical threat. A family man desperately driven to villainy.
    • Johnathan Ohn, A.K.A. The Spot - Spider-Man: Across The Spider-Verse (2023) Played by Jason Schwartzman. Multiversal powers make him the single biggest threat to any Spider-Man.
    • Miguel O'Hara, A.K.A. Spider-Man 2099 - Spider-Man: Across The Spider-Verse (2023) Played by Oscar Isaac. A good man driven to desperate measures. Terrifyingly single-minded anti-hero.
    • Wilson Fisk, A.K.A. Kingpin - Spider-Man: Into The Spider-Verse (2018) Played by Liev Schreiber. Larger than life villain who lives up to the Marvel comics original.
    • Green Goblin. Norman Osborn, who became the Green Goblin, ranks at the top of this list as the most iconic Spider-Man villain of all time. Like many other Spider-Man villains, he is intelligent and cunning.
    • Doctor Octopus. Many people would rank Doc Ock at the top of their lists of greatest Spider-Man villains, but he falls short at the number two spot on our list.
    • Venom. While Venom has become some sort of an antihero today, he was initially a villain born when an alien Symbiote bonded with Spider-Man and turned him into an evil version of himself.
    • Kingpin. The thing about Wilson Fisk, aka the Kingpin, is that he has reached the pinnacle of human physical strength while he doesn’t have any superpowers.
  2. Apr 16, 2014 · Spider-Man has a wide variety of villains, one of the most iconic and well-balanced in comics. The classics are other creatures of the animal kingdom like Rhino, Scorpion, and Doctor Octopus....

  3. Dec 7, 2021 · 1. Doctor Octopus. The man, the myth, the legend – Doc Ock is the greatest, most iconic Spider-Man villain of all time. Dr. Otto Octavius first appeared in The Amazing Spider-Man #3 in 1963, working at the US Atomic Research Centre facility.

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  5. Apr 16, 2024 · From Kingpin to the Green Goblin, these fantastic Marvel villains have given Spider-Man plenty to think about over the years.

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