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1. • • The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer’s disease (AD), the most common neurodegenerative disorder in the elderly.
     www.ncbi.nlm.nih.gov/pmc/articles/PMC7119290/

     Current understanding of metal ions in the pathogenesis of ...

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   What is the role of metal ions in Alzheimer's disease?

   • The homeostasis of metal ions is essential for maintaining normal functions of the brain. In AD patients, changes in the dynamic balance of the metal ions in the brain are closely related to the Aβ deposition and tau hyperphosphorylation/accumulation, suggesting a crucial role of the metal irons in the pathogenesis of AD.

   Current understanding of metal ions in the pathogenesis of Alzheimer’s

   translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00189-z

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   Why is homeostasis of metal ions important?

   • The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer’s disease (AD), the most common neurodegenerative disorder in the elderly.

   Current understanding of metal ions in the pathogenesis of Alzheimer’s

   translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-020-00189-z

   See all results for this question

   Is oxidative stress related to Alzheimer's disease?

   • Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer's disease (AD), the most common neurodegenerative disorder in the elderly. Main body: Erroneous deposition/distribution of the metal ions in different brain regions induces oxidative stress.

   Current understanding of metal ions in the pathogenesis of Alzheimer's …

   pubmed.ncbi.nlm.nih.gov/32266063/

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   Can metal chelation help treat Alzheimer's disease?

   • Dyshomeostasis of metals drives inflammation, β-amyloid, tau and neurodegeneration. Metal chelation is a promising strategy for the management of AD. Better understanding of metals in the brain may help in the treatment of AD. Alzheimer's disease (AD) is a neurodegenerative disorder that leads to cognitive impairment and dementia in the elderly.

   Metal Toxicity Links to Alzheimer's Disease and

   www.sciencedirect.com/science/article/pii/S0022283619300270

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   What causes Alzheimer's disease & related dementias?

   • Risk for Alzheimer’s disease and related dementias is partially attributable to environmental factors. The heavy metals lead, cadmium, and manganese are widespread and persistent in our environments. Once persons are exposed to these metals, they are adept at entering cells and reaching the brain.

   Heavy Metals Exposure and Alzheimer’s Disease and Related Dementias

   www.ncbi.nlm.nih.gov/pmc/articles/PMC7454042/

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   Why is homeostasis important in the brain?

   • Background: The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions.

   Current understanding of metal ions in the pathogenesis of Alzheimer's …

   pubmed.ncbi.nlm.nih.gov/32266063/

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3. link.springer.com › article › 10Role of metals in Alzheimer’s disease | Metabolic Brain Disease

   link.springer.com › article › 10

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   Jul 27, 2021 · As the first cells to interact with metals once they pass the BBB, astrocytes are important mediators of metal homeostasis (Yang et al. 2019). If BBB integrity is compromised, this could explain abnormalities in metal and protein transport into and out of brain parenchyma (Hinkebein et al. 2003).

   • Author: Nikita Das, James Raymick, Sumit Sarkar

   • Publish Year: 2021

4. translationalneurodegeneration.biomedcentral.comCurrent understanding of metal ions in the pathogenesis of ...

   translationalneurodegeneration.biomedcentral.com

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   Apr 3, 2020 · The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the brain is crucial for maintaining normal physiological functions. Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer’s disease (AD), the most common neurodegenerative disorder in the elderly.

   • Author: Lu Wang, Ya-Ling Yin, Xin-Zi Liu, Peng Shen, Yan-Ge Zheng, Xin-Rui Lan, Cheng-Biao Lu, Jian-Zhi Wang

   • Publish Year: 2020

5. Videos

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     4:00

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     How Alzheimer's Changes the Brain

     23 Aug 2017

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     6:27

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     Mechanisms and secrets of Alzheimer's disease: exploring the brain

     11 Oct 2013

     645.2K views

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     nia.nih.gov

     What Happens to the Brain in Alzheimer's Disease?

     15 Nov 2023

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6. pubmed.ncbi.nlm.nih.gov › 32266063Current understanding of metal ions in the pathogenesis of ...

   pubmed.ncbi.nlm.nih.gov › 32266063

   Apr 3, 2020 · Studies have shown that imbalance of these metal ions in the brain is closely related to the onset and progression of Alzheimer's disease (AD), the most common neurodegenerative disorder in the elderly.

   • Author: Lu Wang, Ya-Ling Yin, Xin-Zi Liu, Peng Shen, Yan-Ge Zheng, Xin-Rui Lan, Cheng-Biao Lu, Jian-Zhi Wang

   • Publish Year: 2020

7. www.ncbi.nlm.nih.gov › pmc › articlesEffect of metal ions on Alzheimer's disease - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 24, 2022 · In‐depth studies have found that metal ions can participate in various mechanisms related to the pathogenesis of AD, such as protein deposition, neurofibrillary tangles (NFTs), oxidative stress, neuroinflammation, and neuronal loss (Su et al. 2007) (see Figure 1 ).

   • DOI: 10.1002/brb3.2527
   • Published: 2022/03

   • Publication: Brain Behav. 2022 Mar; 12(3): e2527.

8. www.ncbi.nlm.nih.gov › pmc › articlesHeavy Metals Exposure and Alzheimer’s Disease and Related ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Risk for Alzheimer’s disease and related dementias is partially attributable to environmental factors. The heavy metals lead, cadmium, and manganese are widespread and persistent in our environments. Once persons are exposed to these metals, they are adept at entering cells and reaching the brain.

   • Author: Kelly M Bakulski, Young Ah Seo, Ruby C Hickman, Daniel Brandt, Harita S Vadari, Howard Hu, Sung Kyun...
   • DOI: 10.3233/JAD-200282

   • Publish Year: 2020
   • Published: 2020

9. www.ncbi.nlm.nih.gov › books › NBK552144The Role of Trace Metals in Alzheimer’s Disease

   www.ncbi.nlm.nih.gov › books › NBK552144

   Dec 20, 2019 · Essential trace metals such as zinc, copper, and iron play important roles in healthy brain function but altered homeostasis and distribution have been linked to neurodegenerative diseases and aging. In addition, the presence of non-essential trace metals such as aluminum has been associated with AD.

10. www.sciencedirect.com › science › articleMetal Toxicity Links to Alzheimer's Disease and ...

    www.sciencedirect.com › science › article

    Apr 19, 2019 · Dyshomeostasis of metals drives inflammation, β-amyloid, tau and neurodegeneration. •. Metal chelation is a promising strategy for the management of AD. •. Better understanding of metals in the brain may help in the treatment of AD. Abstract.