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  1. Jun 29, 2022 · If a person with depression wants to try a combination treatment and is willing to accept the possibility of an increased side-effect burden (see recommendation 1.9.8), consider referral to a specialist mental health setting or consulting a specialist. Treatment options include:

  2. Treatment for depression usually involves a combination of self-help, talking therapies and medicines. The treatment recommended will be based on the type of depression you have. Mild depression. If you have less severe (mild) depression, the following treatments may be recommended. Wait and see

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    There is clear evidence that drug-based and psychological therapies are effective treatments for depression. How these therapies compare with each other, alone or in combination, is less clear. Previous studies suggested the combination might be more effective than either alone but were not conclusive. Combination treatment is likely to be more exp...

    This meta-analysis included 101 trials, with 11,910 participants. The most commonly used psychotherapy was CBT, and the most commonly used group of drugs were the selective serotonin reuptake inhibitors (SSRIs). The researchers considered that patients had responded to therapy if their symptoms of depression were reduced by half. They found that pa...

    This research suggests that, for people with moderate depression, combination treatment should be offered before antidepressants alone. Where a single treatment is chosen, the results suggest that psychological treatment is more acceptable to patients than drug treatment. The added benefit of combined treatment is greatest for those with the highes...

    New NICE guidelines on depression in adults are planned. The existing NICE guidelines, published in 2009, recommend a stepped-care model for those with mild to moderate depression. Either psychological therapy or antidepressant drugs were offered only after earlier steps have been exhausted. The recent NICE clinical knowledge summary(March 2020) re...

    The full paper: Cuijpers P, and others. A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry.2020;19:92–107. NICE Clinical Knowledge Summary: Depression(revised in 2020) NICE guidelines 2009: Depression in adults: recognition and management CLinical...

  3. Feb 4, 2021 · People with severe depression symptoms or other conditions, such as chronic illnesses, may be good candidates for this combination. Combination therapy as first-line treatment Success rates of ...

  4. May 26, 2020 · In addition to relieving depression, combination therapy may help ward off recurrences. A classic three-year study reported in JAMA tracked recurrences of major depression in about 200 people ages 60 or older. Of those who received monthly interpersonal therapy and who also took an antidepressant medication, 80% avoided a recurrence.

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  5. Jul 18, 2022 · depression in people with a diagnosis of personality disorder. psychotic depression. electroconvulsive therapy for depression. transcranial magnetic stimulation for depression. implanted vagus nerve stimulation for treatment-resistant depression. access, coordination and delivery of care. For a complete set of recommendations, refer to the full ...

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  7. Aug 17, 2022 · At the end of the 16-week treatment phase, there were no differences in response rates between therapy and medication, with 58% of both treatment groups showing improvement. After 16 weeks ...

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