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- Motor symptoms remain central to the diagnosis of Parkinson's disease, but neuropsychiatric signs and symptoms are gaining recognition as being of similar relevance in many cases, and Parkinson's disease can now be conceptualised as a complex neuropsychiatric disorder.
www.thelancet.com/journals/laneur/article/PIIS1474-4422(21)00330-6/fulltextThe neuropsychiatry of Parkinson's disease: advances and ...
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In people with Parkinson's disease, neuropsychiatric signs and symptoms are common throughout the disease course. These symptoms can be disabling and as clinically relevant as motor symptoms, and their presentation can be similar to, or distinct from, their counterparts in the general population.
The hallmark neuropathophysiological changes that occur in PD, plus the association between exposure to dopaminergic medications and certain psychiatric disorders, suggest a neurobiological basis for many psychiatric symptoms, although psychological factors are involved as well.
- Daniel Weintraub, Daniel Weintraub, Eugenia Mamikonyan
- 2019
Jan 1, 2022 · A systematic review of longitudinal studies identified several factors associated with risk of neuropsychiatric signs and symptoms, including age (increasing or decreasing with age depending on the disorder), sex (male or female depending on the disorder), disease severity, and dopaminergic therapy.29.
Affective disorders, cognitive decline, and psychosis have long been recognized as common in Parkinson disease (PD), and other psychiatric disorders include impulse control disorders, anxiety symptoms, disorders of sleep and wakefulness, and apathy.
- Daniel Weintraub, Daniel Weintraub, Eugenia Mamikonyan
- 2019
Fast forwarding 25 years, although PD is still considered a movement disorder and is diagnosed on that basis, the high prevalence of cognitive impairment and numerous psychiatric complications suggests that it is more accurately conceptualized as a neurocognitive-psychiatric disorder.
- Daniel Weintraub, David J. Burn
- 10.1002/mds.23664
- 2011
- 2011/05
Jul 10, 2024 · In this article we describe the spectrum of neuropsychiatric symptoms encountered in Parkinson's, necessarily limiting the scope to cover manifestations in idiopathic Parkinson's disease rather than the full spectrum of Parkinsonian syndromes.
Neuropsychiatric aspects of Parkinson's disease. J Neural Transm (Vienna). 2019 Jul;126 (7):889-896. doi: 10.1007/s00702-019-02019-7. Epub 2019 May 29. Authors. Anna Nagy 1 , Anette Schrag 2. Affiliations. 1 Department of Clinical and Movement Neurosciences, UCL Institute of Neurology, University College London, London, NW3 2PF, UK.
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