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Can LSD treat generalized anxiety disorder?
Can LSD help treat depression & anxiety?
Can LSD be used in psychiatry?
Can lysergic acid diethylamide help treat anxiety?
Mar 7, 2024 · One dose of LSD in a clinical trial significantly improved anxiety and lasted for 12 weeks, convincing the FDA to give the drug a breakthrough therapy designation.
- 3 min
- Overview
- Results from mice study
- Studies with humans
- Positive effect on brain cell connectivity
- Study limitations
- Takeaway
- GeneratedCaptionsTabForHeroSec
•Psychedelic compounds have gained increased attention as potential therapeutic agents in mental health, especially in low- and non-hallucinogenic doses.
•A new study shows that repeated doses of lysergic acid diethylamide (LSD) over time are effective in reducing symptoms of stress-related anxiety and depression.
•Current investigation sheds light on previously unexplained mechanisms of action, pointing to the serotonin reuptake inhibitor-like effects of LSD.
A new study found that psychedelic drugs such as lysergic acid diethylamide (LSD) may be effective at reducing symptoms of stress-related anxiety and in mental health treatment.
The study’s research team was led by Dr. Gabriella Gobbi, a professor in the Department of Psychiatry at the Research Institute of the McGill University Health Center (RI-MUHC) in Montreal, Canada.
The study, published in the journal Neuropsychopharmacology, also involved eight other neuroscientists and a collaboration between RI-MUHC, Vita-Salute San Raffaele University, Italy, and the Pharmaceutical and Pharmacological Sciences center at the University of Padua, Italy.
The researchers administered low doses of LSD to a group of 8-12-week old male mice over seven days; they weighed 25-30 grams. The mice were exposed to chronic restraint stress conditions and then given variable doses of LSD.
Head twitch responses representing the research target protocol were recorded and were commensurate with the varying amounts of LSD administered to the mice. Doses were repeated at specified time intervals to assess their behavioral and neurobiological responses.
The results showed that the intraperitoneal administration of LSD did not produce antidepressant or anti-anxiety effects in non-stressed mice. The administration of the mid-range dose of LSD per the protocol to the stressed mice prevented anxiety-like behaviors induced by stress and cellular changes in the brain induced by stress.
Repeated LSD administration also protected against worsening anxiety-like behaviors following chronic stress exposure, suggesting an anti-anxiety effect of repeated LSD under anxiety-provoking conditions.
The researchers found that although low dose LSD activated only the transmission of serotonin, higher doses, which stimulated the dopamine system, caused psychotic effects.
According to study results, low dose LSD increases the nervous transmission of serotonin, as do members of the drug class known as selective-serotonin-reuptake-inhibitors (SSRIs). These drugs are a class of antidepressants commonly used for stress-induced anxiety and depression.
One study on healthy human subjects showed that treatment with LSD produced feelings of happiness, trust, empathy, positive social effects, and altruism when used as an adjunctive to psychotherapy.
More studies are needed to show LSD’s efficacy and mechanisms of action in treating depression and anxiety in humans. Earlier studies by Dr. Gobbi and her colleagues explored the adverse side effects of LSD.
Dr. Gobbi’s study discovered that low doses of LSD promoted new dendritic spines in rodents which are nerve branches that transmit electrical signals between nerve cells such as those found in the brain. These nerve branches can become damaged due to chronic stress, and evidence showed that LSD repaired these structures in the mice.
Dr. Gobbi told Medical News Today, “We were surprised about the neuroplastic effects of LSD, in particular the augmentation of spines in stressed mice, which indicates that LSD can facilitate new synapses.”
MNT spoke with Eric Hollander, MD, a professor of Psychiatry and Behavioral Sciences at Albert Einstein College of Medicine and the Psychiatric Research Institute of Montefiore Einstein in New York City, New York.
Regarding study limitations, Dr. Hollander stated:
“The study did not assess for the effects of LSD on depression, did not see any anti-anxiety effects in mice who were not stressed, did not study effects in females and did not study effects of single doses of LSD.”
“This study used repeated dosing rather than intermittent dosing, and showed the prevention of the development of anxiety in mice, rather than treating individuals who already had an anxiety disorder.”
When asked how her results could lead to future treatments, Dr. Gobbi explained to MNT, “One small published clinical trial has suggested that LSD may alleviate anxiety in life-threatened patients. These animal data can support the mechanism of action of this clinical effect.”
Dr. Hollander told MNT that recent research has increasingly studied the links between psychedelic medications and depression, anxiety, PTSD, drug addiction, and cancer.
A study on mice found that repeated low doses of LSD over time prevented anxiety-like behaviors and brain cell damage caused by chronic stress. The study also revealed the serotonin reuptake inhibitor-like effects of LSD and its potential as an adjunct to psychotherapy.
Jan 3, 2024 · MindMed, a biotech company, reports that MM-120, a lysergide-based drug candidate, reduced anxiety symptoms in 78% of patients with generalized anxiety disorder (GAD) four weeks after a single dose. The study results are preliminary and need further validation, but suggest that LSD could be a potential new treatment for GAD.
Jan 21, 2020 · Lysergic acid diethylamide (LSD) was studied from the 1950s to the 1970s to evaluate behavioral and personality changes, as well as remission of psychiatric symptoms in various disorders. LSD was used in the treatment of anxiety, depression, psychosomatic diseases and addiction.
- Juan José Fuentes, Francina Fonseca, Matilde Elices, Magí Farré, Marta Torrens
- 10.3389/fpsyt.2019.00943
- 2020
- Front Psychiatry. 2019; 10: 943.
Oct 7, 2022 · A Phase II clinical trial investigating the efficacy of the psychedelic compound lysergic acid diethylamide (LSD) in combination with psychotherapy for the treatment of anxiety has reported positive results in the journal Biological Psychiatry.
Emerging research shows that psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, might have promise for the treatment of psychiatric illnesses, such as anxiety disorders and depression.
Aug 25, 2022 · The first patient received a dose of a pharmaceutically optimized form of lysergic acid diethylamide (LSD) in the phase 2b dose-optimization trial for MM-120 for the treatment of generalized anxiety disorder (GAD), according to biopharmaceutical company MindMed. 1.
