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- A specific mutation in the ADAMTS17 gene is responible for lens luxation in most affected breeds. A genetic test is avilable to identify affected and carrier dogs. However, in some breeds (including Shar pei, Bassett Griffon Vendeen, Brittany spaniel) the condition is due to a different mutation Genetic tests for hereditary eye diseases.
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Can a genetic test predict a dog's lens luxation?
What causes primary lens luxation (PLL) in dogs?
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Does ADAMTS17 cause primary lens luxation (PLL) in dogs?
After years of research, a genetic test is now available to assess the individual dog’s genotype to try to predict whether a dog is going to develop lens luxation. Wisely used, this tool will help us to reduce primary lens luxation in the future. This article will give an overview on lens anatomy, physiology and function.
Complete lens luxation typically occurs at the age of 3-8 years. How is it inherited? The disease is described as an autosomal-recessive condition. This means that a dog must inherit two copies of an abnormal gene (one from its mother and one from its father) before its health is affected.
Matings between two carriers are predicted to produce 25% primary lens luxation-affected puppies. Dogs with PLL/PLL genotype will have or are at risk of developing primary lens luxation, a condition that can lead to blindness if untreated. They will transmit this variant to all of their offspring.
- No copies of the PLL mutation. Dog is normal.
PLL can be inherited or acquired. Therefore the disease might also affect genetically free dogs. First clinical signs of the inherited form of PLL are detectable at the very young age of 20 months. A complete lens luxation typically occurs at the age of 3 to 8 years.
A variant in the ADAMTS17 gene causes primary lens luxation (PLL). It is inherited in a codominant or additive fashion, meaning dogs with two copies of the variant are at the highest risk of developing the disease. Testing for this gene can help breeders select appropriate mating pairs.
A specific mutation in the ADAMTS17 gene is responible for lens luxation in most affected breeds. A genetic test is avilable to identify affected and carrier dogs. However, in some breeds (including Shar pei, Bassett Griffon Vendeen, Brittany spaniel) the condition is due to a different mutation Genetic tests for hereditary eye diseases.
How to find out if a potential mate has been DNA tested. The Kennel Club’s Health Test Results Finder allows you to find the results of DNA tests carried out as part of The Kennel Club's official DNA testing schemes for any dog on The Kennel Club’s Breed Register.
