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Systems biology involves the development and application of systems theory concepts for the study of complex biological systems through iteration over mathematical modeling, computational simulation and biological experimentation.
Systems biology is a biology‐based inter‐ disciplinary study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (holism instead of reduction) to study them.
- Computational Challenges in Building Stochastic Models
- The Rise of Hybrid Modeling
- Re-Programming Signaling Process in A Cell
Experiments have conclusively proved that molecular activity, including gene regulation, are stochastic (Elowitz 2002). The intrinsic stochasticity of biochemical processes such as transcription and translation generated intrinsic noise; and the fluctuations in the amounts or states of other cellular components lead indirectly to variation in the e...
Pure stochastic modeling deals with biological systems as physical systems without biological semantics. Besides the huge burden of time consumption, specific semantic of gene/protein interaction is often buried under low level biochemical reactions. Hybrid modeling can have multiple meanings. First of all, a model containing metabolic and signalin...
One aspect that signaling modeling can make contribute to is the re-programmability of molecular networks, which has been an important research topic (Tada et al. 2001; Hakelien 2002). Carina Dennis, Natures Australia correspondent, describes the technique of turning an adult human cell back to an embryonic state as cellular alchemy . Usually, from...
- Bin Hu, Pawan K. Dhar
- 2015
Our free digital slide collections cover science topics ranging from algae to zoology. Slides in each slide set contain annotated speaker's notes, references, and keywords. Many of the slide sets are directly related to items in the BioEd Online video library.
Systems biology looks at these networks across scales to integrate behaviors at different levels, to formulate hypotheses for biological function and to provide spatial and temporal insights into dynamical biological changes.
May 14, 2015 · Good systems biology is a balance between reductionism—breaking a system apart into smaller parts and defining the function of these parts—and synthesis—understanding how the parts cooperate to produce the behavior of the whole.
Nov 10, 2010 · Here, we review the state of the field with a focus on four emerging applications of systems biology that are likely to be of particular importance during the decade to follow: (a) pathway-based biomarkers, (b) global genetic interaction maps, (c) systems approaches to identify disease genes, and (d) stem cell systems biology. We also cover ...
