Search results
5 days ago · In patients with acute coronary syndrome (ACS) who undergo coronary stenting, dual‐antiplatelet therapy (DAPT) consisting of aspirin and a P2Y12 inhibitor (prasugrel, ticagrelor, or clopidogrel) for 12 months is the recommended reasonable approach to limit the risk of stent thrombosis and recurrent myocardial infarction (class I indication). 1 However, in the case of high‐potency DAPT, the ...
1 day ago · Background Clinical outcome prediction based on acute-phase ischemic stroke data is valuable for planning health care resources, designing clinical trials, and setting patient expectations. Existing methods require individualized features and often involve manually engineered, time-consuming postprocessing activities. Purpose To predict the 90-day modified Rankin Scale (mRS) score with a deep ...
3 days ago · We thank our CANVAS Trial advisory panel consultants: Ethan Basch MD, Robert D'Agostino MD, Thomas Delate PhD MS, and Randolph Fenninger J.D. We thank our PCORI project officer Kim Bailey MS. We thank all of our research operations teams at PCORI and the Alliance Foundation Trials, LLC as well as the research and clinical teams at all of our recruiting sites who made this trial possible.
1 day ago · Key Points. Question How do hospital early warning scores compare with one another?. Findings In this cohort study that compared 6 early warning scores across 362 926 patient encounters, eCARTv5, a machine learning model, identified clinical deterioration best with an area under the receiver operating characteristics curve (AUROC) of 0.895 and the highest positive predictive values at both the ...
2 days ago · Background Increasing evidence supports the role of advanced glycation end products (AGEs) in atherosclerosis in both diabetic and non-diabetic patients, suggesting that therapeutic strategies targeting AGEs may offer potential benefits in this population. The Mediterranean diet is associated with improved biomarkers and anthropometric measurements related with atherosclerosis in addition to ...
12 hours ago · For the first time, this study compares the local structure and dynamics of hydration water around different segments of some of the natural mutants of α-synuclein, i.e., E46K, G51D, A30P, and A53E, with that of the wild-type protein through explicit water MD simulations. The results show that the C-terminal segments of the fast aggregating mutants such as E46K and A30P are less exposed to ...
5 days ago · Thomas J. Wang, MD Gottlieb C. Friesinger II Professor of Medicine Director, Division of Cardiovascular Medicine, Vanderbilt University Medical Center
