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5 days ago · Degraders are typically categorized as either PROteolysis Targeting Chimeras (PROTACs), i.e., bifunctional molecules composed of a binder to the E3 ligase and a binder to the protein target, joined by a linker unit (6); or monovalent for binding to either E3 ligase or target, referred to as molecular glues (7).
1 day ago · Background Fetal alcohol spectrum disorder (FASD) is a significant public health concern, yet there is no internationally agreed set of diagnostic criteria or summary of underlying evidence to inform diagnostic decision-making. This systematic review assesses associations of prenatal alcohol exposure (PAE) and outcomes of diagnostic assessments, providing an evidence base for the improvement ...
4 days ago · In cancer genome analysis, identifying pathogenic alterations and assessing their effects on oncogenic processes is important. Although whole exome sequencing (WES) can effectively detect such ...
1 day ago · Table S1 in Multimedia Appendix 3 contains specific details on the mHealth interventions’ adherence or self-management targets, intervention components, and intended users. The most frequently targeted adherence or self-management concern was taking medication (98/292, 33.6%), followed by exercise (93/292, 31.8%) and diet (73/292, 25%).
4 days ago · An example of the NIR fluorescence signal analysis performed is shown in Figure S1. In line with clinical fluorescence-guided surgery trials, areas that showed a fluorescence signal with a TBR ≥ 1.5 were defined as fluorescence-positive and areas that had a TBR < 1.5 as fluorescence-negative [27], [28], [29]. Using the same quantification ...
1 day ago · Treatment with S1 nuclease significantly decreased the DNA tract length, suggesting the presence of ssDNA gaps along the newly synthesized DNA . This finding was corroborated by an increase in the formation of pRPA (Ser33) foci, a marker for ssDNA, upon KSQ-4279 treatment in sensitive cells relative to insensitive cells ( Fig. 5D ).
5 days ago · RummaGEO is a Gene Expression Omnibus (GEO) search engine that can be used to find matches for user-submitted gene sets or any metadata search term such as disease, phenotype, tissue, cell type, cell line, drug, or gene. To create RummaGEO, gene expression signatures were automatically computed by identifying groups of samples based on sample descriptions in GEO and the uniformly processed RNA ...
