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2 days ago · Scientists in the Nuffield Department of Medicine and the Icahn School of Medicine at Mount Sinai have developed an innovative antibody platform aimed at tackling one of the greatest challenges in treating rapidly evolving viruses like SARS-CoV-2: their ability to mutate and evade existing vaccines and therapies.
4 days ago · Abstract. Mimicry of host protein structures, or ‘molecular mimicry’, is a common mechanism employed by viruses to evade the host’s immune system. Short linear amino acid (AA) molecular ...
5 days ago · Since the onset of the COVID-19 pandemic, continuous viral mutations have led to the gradual inefficacy of existing vaccines and antibodies. To tackle this issue, Dr Shi Yi’s team at Mount Sinai developed the AMETA platform. Dr Shi Yi said, ‘Viral mutation escape is a major challenge; existing antibodies typically bind to only one or two ...
4 days ago · Viruses are already ill-defined, with sub-viral agents (such as viroids and HDV) being defined within the then more nebulous “perivirosphere” 47, but part of “sub-virality” is the implication of virus-like behavior, either in transmission (e.g., via virions), in host impact (e.g., a pathology), or in replication (e.g., a co-opting viral replication machinery). Currently, it is not ...
4 days ago · However, observed frequencies of the four bases in native sequences of the four lineages differed markedly, irrespective of whether the C site was non-mutated or mutated in at least one lineage or multiple lineages (red bar; Fig. 7A and B). Observed frequencies of upstream A of 44.6%, 42.4%, and 47.8% were significantly higher than the predicted 29.9%; similarly, frequencies of downstream U ...
5 days ago · Undetected zoonotic viral transmission from bats to humans could plausibly occur in these settings. A counter-explanation for the higher levels of pre-pandemic serological activity to SCV2 in some areas of the world is the cross-reactivity of antibodies from Plasmodium spp. Infection.
3 days ago · A confluence of events, anchored by German nationalism and virulent anti-Semitism, led ultimately to the depredations of the Nazi regime, which killed 6 million Jews and at least 12 million others between 1933 and 1945 through campaigns of genocide, the horrors of concentration camps, programs of mass starvation, and other atrocities outside of the wartime death toll, which added tens of ...
