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P53 Tumor Suppressor Protein. High Purity, High Activity, Low Endotoxin, Inquiry For Detail.
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High Purity. p53 Protein, Expressed in E. coli. With N-6*His Tag. For Protein Structure & Function Research. 15,000+ Recombinant Proteins.
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3 days ago · p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [5]
1 day ago · Abstract. The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent studies are beginning to unravel how wild ...
3 days ago · The protein p53 contains 4 functional domains 7 : a transactivation domain (amino acids 6-29), a DNA-binding domain (amino acids 95-288), an oligomerization domain (amino acids 318-358), and a C-terminal domain that regulates DNA binding (amino acids 357-393). The protein p53 is a key regulator of cell proliferation and apoptosis in response to DNA damage.
3 days ago · Genetic alterations that affect the function of p53 tumor suppressor have been extensively investigated in myeloid neoplasms, revealing their significant impact on disease progression, treatment response, and patient outcomes. The identification and characterization of TP53 mutations play pivotal ro …
5 days ago · Abstract The tumor suppressor protein p53, a transcription factor playing a key role in cancer prevention, interacts with DNA as its primary means of determining cell fate in the event of DNA damage. When it becomes mutated, it opens damaged cells to the possibility of reproducing unchecked, which can lead to formation of cancerous tumors. Despite its critical role, therapies at the molecular ...
1 day ago · For instance, p53 can perform distinct functions in mitochondria, nuclei or the cytoplasm, and this may exert significant influence on the outcomes of p53 activation, which correlates with stressor intensity. 8, 33, 34 Its localization to either mitochondria or nuclei induces differential effects of p53 on autophagy. 35 Our previous work showed ...
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1 day ago · The p53 condensates may serve as amyloid fibril precursors to initiate p53 aggregation, which is associated with oncogenic gain-of-function and various human cancers. M237I and R249S mutations located in p53 core domain (p53C) have been detected respectively in glioblastomas and hepatocellular carcinoma.
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