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4 days ago · TOP 100 PUBS – THE WRESTLERS, CAMBRIDGE. June 2024. Cambridge. Back “home” last weekend before another Mrs RM raid on the map of Europe, just long enough to admire the view from Sunnyside, Greater Waterbeach‘s top tourist attraction (4.8 on Trip Advisor).
4 days ago · EMERGING today from the Tardis-like shed that is Martin Howey Classics (Est. 25 years) is a 1970 Triumph Herald 13/60 convertible which is a factory original. Finished in Triumph Valencia Blue, it has very little use for the past year or so.
2 days ago · Background Townes-Brocks syndrome (TBS) is a rare genetic disorder characterized by imperforate anus, dysplastic ears, thumb malformations, and other abnormalities. Previous studies have revealed that mutations in the SALL1 gene can disrupt normal development, resulting in the characteristic features of Townes-Brocks syndrome. Spalt-like transcription factors (SALLs) are highly conserved ...
1 day ago · Genovese and her group found that in prenatal SMA mice, structures called primary cilia were shortened on a type of brain cell that is important for memory and learning. They also discovered that treating these cells in culture with risdiplam elongated the primary cilia.
5 days ago · Cilia that are fixed to an immobile surface, as opposed to a swimming cell, are used to pump fluid in many biological contexts (Elgeti et al., 2015). Typically, during the power stroke, a cilium is straight and moves in a plane perpendicular to the surface, whereas during the recovery stroke it becomes curved and tends to move parallel to the substrate, hence overcoming the scallop theorem.
1 day ago · Kaimori JY, Nagasawa Y, Menezes LF, Garcia-Gonzalez MA, Deng J, Imai E, Onuchic LF, Guay-Woodford LM, and Germino GG Polyductin undergoes Notch-like processing and regulated release from primary cilia Hum Mol Genet 2007 16 942-956
1 day ago · For IHC, we used a cross-reactive commercial anti-acetylated α-tubulin antibody, which allows for visualization of neurons and cilia in a broad range of invertebrate species [14,15,16,17,18,19,20]. We first assayed this antibody in cleared P. miniata post-metamorphic juveniles, defined by bearing only two pairs of secondary tube feet in each ray (2-TF stage) (Fig. 3 A; Fig. S2A).
