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      • Parkinson's disease was first medically described as a neurological syndrome by James Parkinson in 1817, though fragments of Parkinsonism can be found in earlier descriptions (Parkinson 1817).
      www.ncbi.nlm.nih.gov/pmc/articles/PMC3234454/

      The History of Parkinson's Disease: Early Clinical ...

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  3. en.wikipedia.org › wiki › History_of_Parkinson's_diseaseHistory of Parkinson's disease - Wikipedia

    The history of Parkinson's disease expands from 1817, when British apothecary James Parkinson published An Essay on the Shaking Palsy, to modern times. Before Parkinson's descriptions, others had already described features of the disease that would bear his name, while the 20th century greatly improved knowledge of the disease and its ...

  4. www.ncbi.nlm.nih.gov › pmc › articlesThe History of Parkinson's Disease: Early Clinical ...

    Early treatments of Parkinson's disease were based on empirical observation, and anticholinergic drugs were used as early as the nineteenth century. The discovery of dopaminergic deficits in Parkinson's disease and the synthetic pathway of dopamine led to the first human trials of levodopa.

    • Christopher G. Goetz
    • 10.1101/cshperspect.a008862
    • 2011
    • 2011/09

  5. www.ncbi.nlm.nih.gov › pmc › articlesMilestones of Parkinson’s Disease Research: 200 Years of ...

    Sep 11, 2017 · Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Since its first description as a neurological disorder by James Parkinson (1755–1824) in 1817, many important discoveries have been made during this 200 years of PD research history.

    • Song Li, Weidong Le
    • 10.1007/s12264-017-0178-2
    • 2017
    • Neurosci Bull. 2017 Oct; 33(5): 598-602.

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  7. www.nature.com › articles › nrneurolParkinson's disease — the story of an eponym - Nature

    Dec 8, 2017 · History. Parkinson's disease. Abstract. One of the most prevalent neurodegenerative diseases worldwide is still referred to as 'Parkinson's disease'. The condition is named after James Parkinson...

    • Michel Goedert, Alastair Compston
    • 2018

  8. www.nature.com › articles › nrnThe two-century journey of Parkinson disease research - Nature

    Mar 17, 2017 · In his 1817 monograph, James Parkinson described a handful of patients who had a singular association of tremor at rest, slowness (bradykinesia) of or, in some cases, an absence of, voluntary ...

    • Serge Przedborski
    • sp30@cumc.columbia.edu
    • 2017

  9. pubmed.ncbi.nlm.nih.gov › 22229124The history of Parkinson's disease: early clinical ... - PubMed

    Early treatments of Parkinson's disease were based on empirical observation, and anticholinergic drugs were used as early as the nineteenth century. The discovery of dopaminergic deficits in Parkinson's disease and the synthetic pathway of dopamine led to the first human trials of levodopa.

  10. perspectivesinmedicine.cshlp.org › content › 1The History of Parkinson’s Disease: Early Clinical ...

    In the years after these pioneering papers, the concepts of neural circuits evolved with key nuclei of importance to the clinical presen-tation of Parkinsonism being the substantia nigra, the globus pallidus, and the caudate nucleus and putamen (striatum).

  1. neuros.creative-biolabs.com

    AdParkinson's Disease - Genetic Risk Factors for HD

    Neuroscience CRO. In Vivo/Vitro Models of Neurodegenerative Diseases, AD, PD, ALS, HD, MS. Develop Neuroanalytic Techniques and Methods. Provide Great Services for Neuroscience. Act

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