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1. • Processing of antigen peptides

     • Perhaps best characterized is the role of the ER in the processing of antigen peptides and the subsequent peptide assembly into MHC class I and II molecules. Such MHC/tumor-derived peptide complexes are pivotal for the correct recognition of altered self or viral peptides and the subsequent clonal expansion of tumor-reactive T-cells.
     www.frontiersin.org/research-topics/2656/endoplasmic-reticulum-and-its-role-in-tumor-immunity

     Endoplasmic Reticulum and Its Role in Tumor Immunity

2. People also ask

   How does ER stress affect the endoplasmic reticulum?

   • Collectively, these harsh conditions alter the protein-folding capacity of the endoplasmic reticulum (ER) in both cancer cells and infiltrating immune cells, thereby promoting accumulation of misfolded or unfolded proteins within this organelle and, consequently, ER stress.

   Endoplasmic reticulum stress signals in the tumour and its

   www.nature.com/articles/s41568-020-00312-2

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   How does ER stress affect tumor growth?

   • During tumorigenesis, the high proliferation rates of cancer cells require increased activities of ER protein folding, assembly and transport, which are conditions that can induce physiological ER stress. 8 The ER stress response is considered cytoprotective and is involved in tumor growth and adaptation against harsh environments. 9, 10

   Endoplasmic Reticulum Stress and Cancer - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4204165/

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   What is endoplasmic reticulum (ER)?

   • The endoplasmic reticulum (ER) is the principal intracellular organelle responsible for protein folding, translocation and post-translation modification.

   Endoplasmic Reticulum Stress and Cancer - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4204165/

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   What is the role of ERS in tumor cell proliferation?

   • This process is closely related to ERS, which enhances the ability of tumor cells to adapt to unfavorable environments and promotes the malignant progression of cancer. In this paper, we review the roles and mechanisms of ERS in tumor cell proliferation, apoptosis, metastasis, angiogenesis, drug resistance, cellular metabolism, and immune response.

   Endoplasmic reticulum stress—a key guardian in cancer

   www.nature.com/articles/s41420-024-02110-3

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   Does ER stress cause cancer?

   • ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR.

   Endoplasmic Reticulum Stress and Cancer - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4204165/

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   Which ER resident proteins are involved in tumor survival?

   • Other ER resident proteins that participate in tumor survival include ATF4, which is increased in severe hypoxic conditions in human breast cancer tissues, 24, 25 and spliced XBP1, which is increased in breast cancer, lymphoma and glioblastoma cells.

   Endoplasmic Reticulum Stress and Cancer - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4204165/

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3. www.nature.com › articles › s41420/024/02110-3Endoplasmic reticulum stress—a key guardian in cancer | Cell ...

   www.nature.com › articles › s41420/024/02110-3

   Jul 30, 2024 · The endoplasmic reticulum (ER) serves several crucial functions in tumors, including the promotion or inhibition of tumor proliferation, induction of cell apoptosis, enhancement of...

   • Endoplasmic reticulum stress signals in the tumour and its ...

     This Review discusses how ER stress can influence not only...

   • Endoplasmic reticulum stress: molecular mechanism and ...

     The endoplasmic reticulum (ER) functions as a...

4. www.nature.com › articles › s41568/020/00312-2Endoplasmic reticulum stress signals in the tumour and its ...

   www.nature.com › articles › s41568/020/00312-2

   Nov 19, 2020 · This Review discusses how ER stress can influence not only the pro-tumoural features of cancer cells but also reprogramme the function of innate and adaptive immune cells, creating...

   • Author: Xi Chen, Juan R. Cubillos-Ruiz

   • Publish Year: 2021

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6. www.ncbi.nlm.nih.gov › pmc › articlesEndoplasmic Reticulum Stress and Cancer - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR.

   • Author: Raj Kumar Yadav, Soo-Wan Chae, Hyung-Ryong Kim, Han Jung Chae
   • DOI: 10.15430/JCP.2014.19.2.75

   • Publish Year: 2014
   • Publication: J Cancer Prev. 2014 Jun; 19(2): 75-88.

7. www.cell.com › trends › cancerDecoding endoplasmic reticulum stress signals in cancer cells ...

   www.cell.com › trends › cancer

   Jul 8, 2022 · This review summarizes recent advances in understanding the immunoregulatory activity of ER stress in tumors and highlights key alterations in cancer cells that render tumors sensitive to genetic or pharmacological abrogation of UPR elements.

8. www.nature.com › articles › s41392/023/01570-wEndoplasmic reticulum stress: molecular mechanism and ...

   www.nature.com › articles › s41392/023/01570-w

   Sep 15, 2023 · The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated degradation,...

   • Author: Xingyi Chen

9. pubmed.ncbi.nlm.nih.gov › 33214692Endoplasmic reticulum stress signals in the tumour and its ...

   pubmed.ncbi.nlm.nih.gov › 33214692

   In this Review, we discuss the physiological inducers of ER stress in the tumour milieu, the interplay between oncogenic signalling and ER stress response pathways in the cancer cell and the profound immunomodulatory effects of sustained ER stress responses in tumours.

10. www.cell.com › trends › cancerThe UPRising connection between endoplasmic reticulum stress ...

    www.cell.com › trends › cancer

    4 days ago · The tumor microenvironment (TME) represents a dynamic network of cancer cells, stromal cells, immune mediators, and extracellular matrix components, crucial for cancer progression. Stress conditions such as oncogene activation, nutrient deprivation, and hypoxia disrupt the endoplasmic reticulum (ER), activating the unfolded protein response (UPR), the main adaptive mechanism to restore ER ...