Search results
ATP/ADP exchanger
- Heterologous expression of SLC35B1 in E. coli reveals that SLC35B1 is highly specific for ATP and ADP and acts in antiport mode. Moreover, depletion of SLC35B1 from HeLa cells reduces ER ATP levels and, as a consequence, BiP activity. Thus, human SLC35B1 may provide ATP to the ER and was named AXER (ATP/ADP exchanger in the ER membrane).
People also ask
What is the function of the endoplasmic reticulum?
What is Axer in the endoplasmic reticulum?
What role does the ER play in a cell?
What is the agranular endoplasmic reticulum?
The endoplasmic reticulum (ER) is a part of a transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum (RER), and smooth endoplasmic reticulum (SER).
Jun 21, 2024 · endoplasmic reticulum (ER), in biology, a continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells and serves multiple functions, being important particularly in the synthesis, folding, modification, and transport of proteins.
- Kara Rogers
- The endoplasmic reticulum (ER) is a continuous membrane system that forms a series of flattened sacs within the cytoplasm of eukaryotic cells.All e...
- The ER can be classified in two functionally distinct forms: smooth endoplasmic reticulum (SER) and rough endoplasmic reticulum (RER). The morpholo...
- The endoplasmic reticulum (ER) serves important functions particularly in the synthesis, folding, modification, and transport of proteins. Differen...
- The ER was first noted in the late 19th century, when studies of stained cells indicated the presence of some type of extensive cytoplasmic structu...
Aug 28, 2018 · Introduction. In order to play its central role in protein biogenesis, the endoplasmic reticulum (ER) of nucleated cells depends on an Hsp70-type molecular chaperone, termed immunoglobulin heavy chain binding protein (BiP, also called glucose-regulated protein, Grp78) 1, 2.
- Marie-Christine Klein, Katharina Zimmermann, Stefan Schorr, Martina Landini, Patrick A. W. Klemens, ...
- 10.1038/s41467-018-06003-9
- 2018
- Nat Commun. 2018; 9: 3489.
Oct 3, 2015 · The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope.
- Dianne S. Schwarz, Dianne S. Schwarz, Michael D. Blower
- 10.1007/s00018-015-2052-6
- 2016
- Cell Mol Life Sci. 2016 Jan; 73(1): 79-94.
Jan 15, 2021 · The endoplasmic reticulum (ER) is a large organelle made of membranous sheets and tubules that begin near the nucleus and extend across the cell. The endoplasmic reticulum creates, packages, and secretes many of the products created by a cell.
- Gabe Buckley
All eucaryotic cells have an endoplasmic reticulum (ER). Its membrane typically constitutes more than half of the total membrane of an average animal cell (see Table 12-2). The ER is organized into a netlike labyrinth of branching tubules and flattened sacs extending throughout the cytosol (Figure 12-35).
The endoplasmic reticulum is the cell organelle that originates from the cell’s nuclear envelope, synthesizes protein, and transports the proteins for cellular metabolism. Depending on the cell, the endoplasmic reticulum can occupy 50% of the cell volume.
