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May 23, 2021 · Enantioselective analytical methods by LC using CSPs is the primary choice to quantify enantiomers in biological matrices. Despite the use of LC-DAD, LC-UV and LC-FD, the use of LC-MS/MS allows to obtain a better selectivity, sensitivity, and unambiguous identification of the target substances.
- Maria Miguel Coelho, Carla Fernandes, Fernando Remião, Maria Elizabeth Tiritan, Maria Elizabeth Tiri...
- 10.3390/molecules26113113
- 2021
- Molecules. 2021 Jun; 26(11): 3113.
Put more simply: it is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. Enantiomers are stereoisomers that have opposite configurations at every chiral center. Diastereomers are stereoisomers that differ at one or more chiral centers.
Herein, we describe the accessibility of atropisomeric o -quinodimethanes, the enantioselective synthesis of their precursors, their remarkable configurational stability and the stereospecific transformation by the benzannulation of dienophiles.
Jan 1, 2024 · The enantioselectivity of an enzymatic process has been found to depend upon many experimental factors. Effectiveness of a stereoselective biocatalysis depends upon how efficiently these conditions are tuned to achieve a targeted result.
Jan 24, 2022 · This review provides a comprehensive inventory of progress in enantioselective radical reactions with a goal of detailing the reaction mechanisms involved in these transformations such that any nonspecialist could find their own creativity to invent yet unknown applications.
Sep 23, 2024 · Several approaches to enantioselective synthesis have been developed, but the most efficient are those that use chiral catalysts to temporarily hold a substrate molecule in an unsymmetrical environment—the same strategy that nature uses when catalyzing reactions with chiral enzymes.
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We report the first enantioselective addition of pyrazoles to 1,3-dienes. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity.
