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What are statin-associated muscle symptoms (Sams)?
Are muscle symptoms associated with statin treatment?
Why are Sams rates so high after initiation of statin treatment?
Jun 19, 2017 · Advise patients to contact you if they experience muscle symptoms, and not to stop taking their statin. 6 SAMS Assessment Guide See accessible text version of this table below
Sep 10, 2022 · Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance and are associated with increased risk of cardiovascular events that manifest from statin underutilization and discontinuation.
Sep 27, 2017 · Statin-related adverse events (AEs), especially the statin-associated muscle symptoms (SAMS), are the most common reasons for their discontinuation. Therefore, it is important to determine the risk of SAMS in the older population.
- Zhen Zhou, Loai Albarqouni, Monique Breslin, Andrea J Curtis, Mark Nelson
- 2017
Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance. The prevalence of SAMS is estimated to be about 10% (range 5% to 25%), but more than 80% of cases are not caused by the statin.
Sep 24, 2018 · Statins are most frequently associated with mild muscle complaints, termed statin-associated muscle symptoms or SAMS, which include myalgia, cramps, and perceived weakness. These symptoms are the most difficult to diagnose because the time from statin initiation to symptoms, the type of complaints, and their severity varies dramatically among ...
- Beth A. Taylor, Paul D. Thompson
- 10.1007/s13311-018-0670-z
- 2018
- 2018/10
May 3, 2017 · Statin intolerance due to statin-associated muscle symptoms (SAMS) is low in randomized controlled trials (RCTs), but much higher in clinical observation studies. Statin nonadherence is associated with higher rates of cardiovascular events, and is most frequently attributed to SAMS.
Dec 18, 2017 · The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI) is one proposal for differentiating SAMS from nonspecific muscle symptoms . This index assesses SAMS as “probable” (score 9 to 11), “possible” (score 7 to 8), or “unlikely” (score 2 to 6) based on four scales relating to the location, pattern, timing of onset, and timing ...
