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- While concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B-cell lineage.
www.ncbi.nlm.nih.gov/pmc/articles/PMC6842438/Cohesin members Stag1 and Stag2 display distinct roles in ...
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Oct 1, 2020 · Mutations in cohesin associated genes (RAD21, SMC3, STAG2, and others 10,11) may contribute through a similar overall effect as that of DNMT3A and TET2, as Stag2 loss of function in mice has been shown to lead to increased expression of self-renewal genes and decreased expression of differentiation genes 57; nevertheless, much more work needs ...
- Grant A Challen, Margaret A Goodell
- 10.1182/blood.2020006510
- 2020
- Blood. 2020 Oct 1; 136(14): 1590-1598.
Nov 7, 2019 · While concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B-cell lineage.
- Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...
- 10.1016/j.stem.2019.08.003
- 2019
- 2019/11/11
Apr 12, 2023 · Our study also showed STAG2ms to be associated with poor prognosis in MN. There was possible worsening of OS with higher VAF, which may be highlighted with a larger cohort. This, combined with the lack of association between MN classification and OS, suggests an adverse impact of STAG2ms on survival regardless of phenotypic features. There was ...
Nov 7, 2019 · The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation.
- Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...
- 2019
Nov 15, 2022 · STAG2m independently predicted poor prognosis, regardless of MN classification, especially in tMN and with circulating blasts ≥5%. HSCT had a favorable impact on STAG2 m pts. Our study is limited by the small sample size and retrospective nature.
Abstract. Purpose of review. Recurrent loss of function mutations within genes of the cohesin complex have been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). STAG2 is the most commonly mutated cohesin member in AML as well as solid tumors.
Dec 8, 2017 · To investigate the functional role of STAG2 in leukemogenesis as well as normal hematopoiesis, we generated Stag2 conditional knockout (cKO) mice with an Mx1 -cre allele, in which Stag2 deletion was induced by polyIC injection.
