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   Can biologic treatments help people with severe asthma?

   • Find out how specialist biologic treatments called monoclonal antibodies (mAbs) can help people with severe asthma, which ones are available in the UK, and who can access them. What are biologic treatments for asthma? Biologic treatments used for asthma are also known as monoclonal antibodies or mAbs.

   Biologic therapies for severe asthma - Lung UK

   www.asthmaandlung.org.uk/symptoms-tests-treatments/treatments/biologic-therapies

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   Should I talk to a doctor about a biologic treatment for asthma?

   • Always talk to your doctor or specialist team if you’re worried about any of these risks or side effects. Biologic treatments for asthma have an increased risk of a severe allergic reaction (anaphylaxis). The risk is rare (1 in 1000) and more likely if you have a history of allergic reactions or anaphylaxis.

   Biologic therapies for severe asthma - Lung UK

   www.asthmaandlung.org.uk/symptoms-tests-treatments/treatments/biologic-therapies

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   How long does biologic therapy for asthma take to work?

   • Biologic therapy for asthma targets different parts of your immune system to help people who have moderate to severe asthma that inhalers and other medicines can’t manage. Side effects may include headache, joint and back pain and a reaction around the injection site. Results may take a few weeks or months. What is biologic therapy for asthma?

   Biologic Therapy for Severe Asthma - Cleveland Clinic

   my.clevelandclinic.org/health/treatments/17711-biologic-therapy-for-severe-asthma

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   Can omalizumab treat severe asthma?

   • There are now several monoclonal antibody (mAb) therapies (“biologics”) available to treat severe asthma. Omalizumab is an anti-IgE mAb and is licensed in severe allergic asthma. Current evidence suggests it may decrease exacerbations by augmenting deficient antiviral immune responses in asthma.

   A pragmatic guide to choosing biologic therapies in severe asthma

   breathe.ersjournals.com/content/17/4/210144

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   Which biologics target severe eosinophilic asthma?

   • Mepolizumab, reslizumab and benralizumab are all biologics that target severe eosinophilic asthma, by reducing eosinophils. Severe asthma with type 2 inflammation where severe asthma symptoms are driven by both allergies and high levels of eosinophils. Dupilumab is a biologic targeting severe type 2 inflammatory asthma.

   Biologic therapies for severe asthma - Lung UK

   www.asthmaandlung.org.uk/symptoms-tests-treatments/treatments/biologic-therapies

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   Can a biologic armamentarium improve asthma control?

   • The addition of biologics to the therapeutic armamentarium has helped achieve asthma control in patients whose condition remained uncontrolled with prior therapies, and the hope of possibly altering the natural history of this disease creates great hope for the future of asthma care.

   Biologics in severe asthma: A pragmatic approach for choosing the right

   www.resmedjournal.com/article/S0954-6111(23)00302-5/fulltext

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2. www.uhsussex.nhs.uk › resources › biologicBiologic treatments for severe asthma - University Hospitals ...

   www.uhsussex.nhs.uk › resources › biologic

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   Phone number: 07385 947878. or the PALS service, if you would like further advice, support or to make a complaint: Email: uhsussex.pals@nhs.net. Phone number: 01273 664511. Breath Right UK. Asthma & lung UK. This information is intended for patients receiving care in Brighton & Hove or Haywards Heath.

3. www.asthmaandlung.org.uk › biologic-therapiesBiologic therapies for severe asthma | Asthma + Lung UK

   www.asthmaandlung.org.uk › biologic-therapies

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   • Going to A Clinic
   • Self-Injecting at Home
   • How to Store Biologics

   You’ll usually need to attend a specialist asthma clinicto start treatment. If the clinic is not nearby, this can involve travelling so you’ll need to allow for the cost and time around that, which may include costs for childcare or time off work. You may also need to stay in the clinic for a couple of hours after your first few treatments. This is...

   See full list on asthmaandlung.org.uk

   You’ll need to go to the specialist clinic for your injection, but after a few weeks you may be told you can self-inject at home. 1. If you have a history of anaphylaxis your injections should always be given to you by a healthcare professional in the specialist clinic. 2. If you have no history of anaphylaxis you may be able to self-inject at home...

   See full list on asthmaandlung.org.uk

   If you’re using biologics yourself at home, you need to store them safely. Follow all instructions given to you by your healthcare team. You must: 1. store them in the fridge 2. keep them in their original packaging 3. keep them away from light 4. store them out of reach of children 5. use by the expiry date.

   See full list on asthmaandlung.org.uk

4. Videos

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     Biologic Treatments For Asthma: What You Need To Know

     16 May 2018

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     VIDEO: Biologics for severe asthma

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     Webinar: Biologic Therapy for Patients with Severe Asthma

     3 Nov 2023

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5. www.guysandstthomas.nhs.uk › news › majorMajor breakthrough for severe asthma treatment - Guy's and St ...

   www.guysandstthomas.nhs.uk › news › major

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   Dec 15, 2023 · A landmark study has shown that severe asthma can be controlled using biologic therapies, without the addition of regular high-dose inhaled steroids which can have significant side effects.

6. breathe.ersjournals.com › content › 17/4/210144A pragmatic guide to choosing biologic therapies in severe asthma

   breathe.ersjournals.com › content › 17/4/210144

   • Cached

   There are now several monoclonal antibody (mAb) therapies (“biologics”) available to treat severe asthma. Omalizumab is an anti-IgE mAb and is licensed in severe allergic asthma. Current evidence suggests it may decrease exacerbations by augmenting deficient antiviral immune responses in asthma.

7. www.ncbi.nlm.nih.gov › books › NBK604836The Efficacy and Safety of Biologic Drugs to Treat Severe Asthma

   www.ncbi.nlm.nih.gov › books › NBK604836

   May 1, 2024 · Severe asthma has several typologies (Figure 1), and several biologic drugs have been developed to target inflammation in specific subtypes of severe asthma, namely type 2 eosinophilic or allergic. Type 2 inflammatory asthma is predominately caused by type 2 cytokines and lymphocytes.

   • Published: 2024/05

8. my.clevelandclinic.org › health › treatmentsBiologic Therapy for Severe Asthma - Cleveland Clinic

   my.clevelandclinic.org › health › treatments

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   Aug 5, 2024 · Biological therapy for asthma is a relatively new, effective treatment for moderate to severe asthma. It doesn’t just treat your asthma symptoms, but helps to decrease inflammation in your airways. It may take up to several months to notice an improvement in your symptoms.

9. www.resmedjournal.com › article › S0954-6111(23Biologics in severe asthma: A pragmatic approach for choosing ...

   www.resmedjournal.com › article › S0954-6111(23

   May 10, 2023 · Biologics in severe asthma: A pragmatic approach for choosing the right treatment for the right patient. Linda Rogers a ∙ Milos Jesenak b ∙ Leif Bjermer c ∙ Nicola A. Hanania d ∙ Sven F. Seys e ∙ Zuzana Diamant f, g, h, i. Download PDF. Share. Highlights. •.