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     europepmc.org

     • Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression. Loss of both STAG1 and STAG2 causes widespread transcriptome dysregulation, altered cohesin DNA occupancy, and reduced cell proliferation.
     epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

     Distinct and overlapping roles of STAG1 and STAG2 in cohesin ...

2. People also ask

   Why are STAG1 and STAG2 different?

   • STAG1 and STAG2 have independent roles in cohesin localization and both overlapping and distinct roles in gene expression. The roles of STAG1 and STAG2 in mouse embryonic stem cells may be somewhat different than in other cell types, due to their relative expression levels.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

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   Are STAG1 and STAG2 redundant?

   • STAG1 and STAG2 appear to act redundantly at these 2279 genes, with a single STAG able to compensate for the loss of the other STAG protein. This is in contrast to the 1484 genes commonly affected by loss of either STAG1 or STAG2 individually.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

   See all results for this question

   Do STAG1 and Stag2 have overlapping roles in cohesin localization?

   • We report both overlapping roles for STAG1 and STAG2 in cohesin localization and somewhat distinct roles in gene expression. STAG1 and STAG2 occupy the same sites across the genome, yet do not exist together in a higher order complex. Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

   See all results for this question

   Are STAG1 and STAG2 a cohesin?

   • STAG1- and STAG2-cohesin were initially proposed to organize cohesion at telomeres and centromeres, respectively. Here, we uncover redundant and specific roles of STAG1 and STAG2 in gene regulation and chromatin looping using HCT116 cells with an auxin-inducible degron (AID) tag fused to either STAG1 or STAG2.

   Redundant and specific roles of cohesin STAG subunits in chromatin loo…

   pubmed.ncbi.nlm.nih.gov/32253279/

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3. epigeneticsandchromatin.biomedcentral.comDistinct and overlapping roles of STAG1 and STAG2 in cohesin ...

   epigeneticsandchromatin.biomedcentral.com

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   Aug 10, 2020 · Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression. Loss of both STAG1 and STAG2 causes widespread transcriptome dysregulation, altered cohesin DNA occupancy, and reduced cell proliferation.

   • Author: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan,...

   • Publish Year: 2020

4. www.cell.com › cell-stem-cell › fulltextCohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   www.cell.com › cell-stem-cell › fulltext

   Sep 5, 2019 · Here, we demonstrate a non-redundant role of Stag2 and Stag1 in hematopoiesis, with a specific role for Stag2 in regulating the balance between hematopoietic differentiation and self-renewal.

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

5. www.sciencedirect.com › science › articleCohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   www.sciencedirect.com › science › article

   Nov 7, 2019 · Here, we demonstrate a non-redundant role of Stag2 and Stag1 in hematopoiesis, with a specific role for Stag2 in regulating the balance between hematopoietic differentiation and self-renewal. In addition, we show that Stag2-bound loci that are not bound by Stag1 undergo locus-specific changes in local interactions that, in the absence of Stag2 ...

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

6. pubmed.ncbi.nlm.nih.gov › 32253279Redundant and specific roles of cohesin STAG subunits in ...

   pubmed.ncbi.nlm.nih.gov › 32253279

   STAG1- and STAG2-cohesin were initially proposed to organize cohesion at telomeres and centromeres, respectively. Here, we uncover redundant and specific roles of STAG1 and STAG2 in gene regulation and chromatin looping using HCT116 cells with an auxin-inducible degron (AID) tag fused to either STAG1 or STAG2.

   • Author: Valentina Casa, Macarena Moronta Gines, Eduardo Gade Gusmao, Eduardo Gade Gusmao, Johan A. Slotman, ...

   • Publish Year: 2020

7. elifesciences.org › articles › 26980Synthetic lethality between the cohesin subunits STAG1 and ...

   elifesciences.org › articles › 26980

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   Jul 10, 2017 · Thus, STAG1 and STAG2 support sister chromatid cohesion to redundantly ensure cell survival. STAG1 represents a vulnerability of cancer cells carrying mutations in the major emerging tumor suppressor STAG2 across different cancer contexts.

   • Author: Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P Santos, Katrina Falkenberg, ...

   • Publish Year: 2017

8. www.nature.com › articles › s41467/019/09659-zA requirement for STAG2 in replication fork progression ...

   www.nature.com › articles › s41467/019/09659-z

   Apr 11, 2019 · These results demonstrate that STAG2 has unique, non-redundant cellular functions compared to STAG1, whereas the core cohesin ring subunits are essential for viability in primary...

9. www.researchgate.net › publication › 343559648(PDF) Distinct and overlapping roles of STAG1 and STAG2 in ...

   www.researchgate.net › publication › 343559648

   Aug 10, 2020 · Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression. Loss of both STAG1 and STAG2 causes widespread transcriptome...