Yahoo Web Search

Search results

1. • 

     researchgate.net

     • We report both overlapping roles for STAG1 and STAG2 in cohesin localization and somewhat distinct roles in gene expression. STAG1 and STAG2 occupy the same sites across the genome, yet do not exist together in a higher order complex. Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression.
     epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

     Distinct and overlapping roles of STAG1 and STAG2 in cohesin ...

2. People also ask

   Why are STAG1 and STAG2 different?

   • STAG1 and STAG2 have independent roles in cohesin localization and both overlapping and distinct roles in gene expression. The roles of STAG1 and STAG2 in mouse embryonic stem cells may be somewhat different than in other cell types, due to their relative expression levels.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

   See all results for this question

   Do STAG1 and Stag2 have overlapping roles in cohesin localization?

   • We report both overlapping roles for STAG1 and STAG2 in cohesin localization and somewhat distinct roles in gene expression. STAG1 and STAG2 occupy the same sites across the genome, yet do not exist together in a higher order complex. Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

   See all results for this question

   Do STAG1 and Stag2 have overlapping roles in gene expression?

   • STAG1 and STAG2 display partially distinct and overlapping roles in gene expression. a Overlap of differentially expressed genes (DEGs) in Stag1−/− cells compared to wild-type cells and Stag2−/− cells compared to wild-type cells. Cells were treated with siGLO as a transfection control. b Correlation plot of log2 fold changes of DEGs.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

   See all results for this question

   How does STAG2 loss affect hematopoiesis?

   • Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage.

   Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin …

   www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30338-8

   See all results for this question

3. epigeneticsandchromatin.biomedcentral.comDistinct and overlapping roles of STAG1 and STAG2 in cohesin ...

   epigeneticsandchromatin.biomedcentral.com

   • Cached

   Aug 10, 2020 · STAG1 and STAG2 have independent roles in cohesin localization and both overlapping and distinct roles in gene expression. The roles of STAG1 and STAG2 in mouse embryonic stem cells may be somewhat different than in other cell types, due to their relative expression levels.

   • Author: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan,...

   • Publish Year: 2020

4. www.cell.com › cell-stem-cell › fulltextCohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   www.cell.com › cell-stem-cell › fulltext

   Sep 5, 2019 · The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered hematopoietic function, increased self-renewal, and impaired differentiation.

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

5. www.cell.com › cancer-cell › fulltextSTAG2 loss rewires oncogenic and developmental programs to ...

   www.cell.com › cancer-cell › fulltext

   Studies have demonstrated that cohesin complexes containing either STAG1 (cohesin-SA1) or STAG2 (cohesin-SA2) are expressed concurrently in mitotic cells and bind to overlapping, as well as unique, chromatin locations

   • Author: Biniam Adane, Biniam Adane, Gabriela Alexe, Gabriela Alexe, Gabriela Alexe, Bo Kyung A. Seong, Bo Ky...

   • Publish Year: 2021

6. www.nature.com › articles › s41467/023/36900-7Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2

   www.nature.com › articles › s41467/023/36900-7

   Mar 10, 2023 · Here, the authors report that a drastic reduction of NIPBL levels reduces chromatin-bound cohesin-STAG2 genome wide while cohesin-STAG1 increases and can still be found at CTCF-bound sites but...

7. pubmed.ncbi.nlm.nih.gov › 31495782Cohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   pubmed.ncbi.nlm.nih.gov › 31495782

   Nov 7, 2019 · Although concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B cell lineage.

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

8. www.ncbi.nlm.nih.gov › pmc › articlesCohesin members Stag1 and Stag2 display distinct roles in ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 7, 2019 · While concurrent loss of Stag2 and Stag1 abrogated hematopoiesis, Stag2 loss alone decreased chromatin accessibility and transcription of lineage-specification genes, including Ebf1 and Pax5, leading to increased self-renewal and reduced HSPC commitment to the B-cell lineage.

9. www.nature.com › articles › s41594/018/0070-4Distinct roles of cohesin-SA1 and cohesin-SA2 in 3D ... - Nature

   www.nature.com › articles › s41594/018/0070-4

   Jun 4, 2018 · The presence of cohesin-SA1 allows STAG2-deficient cancer cells to survive by ensuring sufficient cohesion between the sister chromatids 9. However, cohesin-SA1 cannot occupy SA2-only sites ...