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1. epigeneticsandchromatin.biomedcentral.comDistinct and overlapping roles of STAG1 and STAG2 in cohesin ...

   epigeneticsandchromatin.biomedcentral.com

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   Aug 10, 2020 · Clustered ChIP-seq signal at a union list of 48,269 STAG1 and STAG2 peaks shows that STAG1 levels and STAG2 levels are correlated, and fails to reveal sites in which a single STAG protein is preferred over the other (Fig. 1d).

   • Author: Nicole L. Arruda, Zachary M. Carico, Megan Justice, Ying Frances Liu, Junjie Zhou, Holden C. Stefan,...

   • Publish Year: 2020

2. www.nature.com › articles › s41467/023/36900-7Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2

   www.nature.com › articles › s41467/023/36900-7

   Mar 10, 2023 · To generate STAG1 and STAG2 KO cell lines, viruses were produced through transfection of 3 × 10 6 293T cells with 9 µg of lentiGuide-Puro (Addgene, #52963) containing guides for STAG1 or STAG2 ...

3. www.cell.com › cell-stem-cell › fulltextCohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   www.cell.com › cell-stem-cell › fulltext

   Sep 5, 2019 · In murine hematopoietic Stag2 deletion, Stag1 rescues topologically associated domains in the absence of Stag2 but cannot restore the chromatin architecture required for hematopoietic lineage commitment. PU.1 target genes lose accessibility and expression. Induced target gene expression, but not PU.1 overexpression, is sufficient to restore differentiation in the altered chromatin state.

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

4. pubmed.ncbi.nlm.nih.gov › 31495782Cohesin Members Stag1 and Stag2 Display Distinct Roles in ...

   pubmed.ncbi.nlm.nih.gov › 31495782

   Nov 7, 2019 · Transcriptional regulators, including the cohesin complex member STAG2, are recurrently mutated in cancer. The role of STAG2 in gene regulation, hematopoiesis, and tumor suppression remains unresolved. We show that Stag2 deletion in hematopoietic stem and progenitor cells (HSPCs) results in altered …

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...

   • Publish Year: 2019

5. www.ncbi.nlm.nih.gov › pmc › articlesCohesin members Stag1 and Stag2 display distinct roles in ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Nov 7, 2019 · Annotation analysis of both Stag1/Stag2 common and Stag2-unique peaks showed enrichment of Stag2-unique ISC peaks within promoter regions compared to Stag1/Stag2 common peaks (fisher’s exact test p<3.03 ×10 −26 for ISC up; p<1.22 ×10 −10 for ISC down; Figure S6A, right panel), suggesting that the ISC seen in Stag2-deficient cells may ...

   • Author: Aaron D. Viny, Robert L. Bowman, Yu Liu, Vincent-Philippe Lavallée, Shira E. Eisman, Wenbin Xiao, Be...
   • DOI: 10.1016/j.stem.2019.08.003

   • Publish Year: 2019
   • Published: 2019/11/11

6. www.nature.com › articles › s41408/022/00683-9Potential role of STAG1 mutations in genetic predisposition ...

   www.nature.com › articles › s41408/022/00683-9

   Jun 2, 2022 · To evaluate the correlation between the different STAG variants and cancer, ... Synthetic lethal interaction between the tumour suppressor STAG2 and its paralog STAG1. Oncotarget. 2017;8:37619–32.

7. People also ask

   Are STAG1 and STAG2 correlated?

   • Clustered ChIP-seq signal at a union list of 48,269 STAG1 and STAG2 peaks shows that STAG1 levels and STAG2 levels are correlated, and fails to reveal sites in which a single STAG protein is preferred over the other (Fig. 1 d).

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

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   Do STAG1 and Stag2 have overlapping roles in cohesin localization?

   • We report both overlapping roles for STAG1 and STAG2 in cohesin localization and somewhat distinct roles in gene expression. STAG1 and STAG2 occupy the same sites across the genome, yet do not exist together in a higher order complex. Despite their shared localization, STAG1 and STAG2 have both distinct and redundant effects on gene expression.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

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   Are STAG1 and STAG2 overlapping?

   • In mESCs, cohesin-STAG1 and cohesin-STAG2 show identical patterns of localization across the genome, and their localization is not dependent on one another. Despite their high degree of genomic overlap, STAG1 and STAG2 do not display strongly overlapping roles in gene expression.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

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   Do STAG1 and Stag2 have overlapping roles in gene expression?

   • STAG1 and STAG2 display partially distinct and overlapping roles in gene expression. a Overlap of differentially expressed genes (DEGs) in Stag1−/− cells compared to wild-type cells and Stag2−/− cells compared to wild-type cells. Cells were treated with siGLO as a transfection control. b Correlation plot of log2 fold changes of DEGs.

   Distinct and overlapping roles of STAG1 and STAG2 in

   epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-020-00353-9

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8. www.nature.com › articles › s41467/019/09659-zA requirement for STAG2 in replication fork progression ...

   www.nature.com › articles › s41467/019/09659-z

   Apr 11, 2019 · Across all four isogenic pairs, STAG2-deficiency correlated with a significant decrease in survival following shRNA depletion of genes responsible for DNA double-strand break repair via either HR ...