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  1. Nov 22, 2012 · Over eight years ago I was prescribed Quinine Sulphate and, until a few months ago, never had even one twinge of cramp of any kind. However, that 'honeymoon' was ended when my specialist said that such prolonged use had irrevocably damaged my kidneys and that I am now CKD at Stage 3 and very likely to progress to Stage 4/5.

  2. Compare Quinine head-to-head with other drugs for uses, ratings, cost, side effects and interactions.

  3. View quinine information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and monitoring requirements.

  4. Quinine was historically used to prevent malaria. Today, it's more commonly used as an ingredient in soft drinks and other beverages. Video of the Day. Because tonic water contains few ingredients, there are few nutritional benefits to drinking it. This beverage essentially has no nutrients.

    • Overview
    • Quinine uses
    • Is quinine safe?
    • Benefits of drinking tonic water
    • Side effects
    • Frequently asked questions
    • Summary

    Tonic water is a soft drink containing quinine, which gives it a bitter taste. Quinine is a common treatment for malaria. Some people believe that it can also help with leg cramps and restless legs syndrome.

    Quinine comes from the bark of the cinchona tree. This tree is native to central and South America, as well as some islands in the Caribbean and western parts of Africa.

    People have consumed quinine in tonic water to help treat cases of malaria for centuries.

    In this article, learn about what quinine is, its side effects, and possible benefits.

    Doctors continue to use quinine as a part of malaria treatment. However, it is typically a second-line treatment option and may have adverse effects at therapeutic doses.

    Researchers cite the poor tolerability of the drug and the risk of severe health consequences as reasons to limit regular medicinal use.

    As a food additive, quinine offers a bitter taste. Manufacturers usually add small amounts to tonic water.

    Some people use tonic water to help treat nighttime leg cramps, but further research is necessary to prove its effectiveness and weigh this against the risk of side effects.

    Experts consider quinine safe to consume in small doses. The United States Food and Drug Administration (FDA) has approved up to 83 parts per million in carbonated beverages.

    The FDA also specifies that manufacturers must place quinine on the label for consumers to easily see.

    Some people may experience allergic reactions to quinine. If this is the case, a person should avoid tonic water and any other products that contain quinine.

    People who should avoid quinine in medications include:

    •people who are pregnant or breastfeeding

    •those with abnormal heart rhythms

    Tonic water may provide the following benefits:

    •Some people believe tonic water helps with nocturnal leg cramps and restless legs syndrome.

    •Some people will enjoy the flavor of tonic water.

    •Drinking tonic water may help people stay hydrated.

    Tonic water is a carbonated soft drink that may contain sugar and has little nutritional value. The quinine present in tonic water provides a distinctive bitter flavor.

    While not dangerous, tonic water does not have any major benefits and could lead to an unnecessary increase in calorie consumption.

    Quinine is very diluted in tonic water. The likelihood of a person experiencing any side effects from drinking tonic water is slim. However, side effects of quinine can include:

    •ringing in the ears

    •vomiting

    •stomach cramps

    •nervousness

    •nausea

    What does quinine do in the body?

    As a malaria medication, quinine kills the parasite that causes malaria. In small doses, such as in a single glass of tonic water, quinine has little effect on the body, and the FDA considers it safe.

    What is quinine in tonic water good for?

    Quinine gives tonic water its bitter taste, which some people enjoy. Tonic water’s original marketing from 1862 claimed: “It’s properties are antacid, cooling, and refreshing…it gives strength to the stomach and tone to the whole nervous system, and is especially adapted to persons feeling depressed from mental or bodily excitement.” There is no scientific evidence to support these claims.

    The quinine in tonic water helps give it a bitter taste. People should not mistake tonic water for a healthful drink, as it may contain sugar and provides no additional nutritional value.

    The quinine in tonic water is very diluted. Some people claim tonic water may help with leg cramps, but this usage is not FDA-approved, and further research is necessary.

  5. Dec 11, 2014 · Quinine should not be considered a routine treatment for nocturnal leg cramps, and should only be considered when cramps cause regular disruption of sleep.

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  7. Dec 9, 1995 · Quinine is widely prescribed as the treatment of choice for nocturnal leg cramps despite doubts about its clinical efficacy. Several commonly prescribed agents, including nifedipine, cimetidine, salbutamol, terbutaline, and diuretics in general, may also cause leg cramps as a side effect. 1 2 In addition, quinine may cause severe visual ...

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