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  1. Francis, Duke of Guise. Francis I of Lorraine, 2nd Duke of Guise, 1st Prince of Joinville, and 1st Duke of Aumale ( French: François de Lorraine; 17 February 1519 – 24 February 1563), was a French general and statesman. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege ...

  2. Assassination of the Duke of Guise, engraved by Jacque Tortorel and Jean Perrissin in 1570. On 24 February 1563, Francis, Duke of Guise was assassinated by the Huguenot Jean de Poltrot during the Siege of Orléans. His death represents a critical turning point in the French Wars of Religion. It would be the first major assassination in what ...

  3. The House of Guise was founded as a cadet branch of the House of Lorraine by Claude of Lorraine (1496–1550), who entered French service and was made the first Duke of Guise by King Francis I in 1527. The family's high rank was not due to possession of the Guise dukedom but to their membership in a sovereign dynasty, which procured for them ...

  4. House of Guise, Noble French Roman Catholic family that played a major role in French politics during the Reformation. Claude de Lorraine (1496–1550) was created the 1st duke de Guise in 1527 for his service to Francis I in the defense of France. Claude’s sons François, 2nd duke de Guise, and.

    • The Editors of Encyclopaedia Britannica
  5. Francis I of Lorraine, 2nd Duke of Guise, 1st Prince of Joinville, and 1st Duke of Aumale ( French: François de Lorraine; 17 February 1519 – 24 February 1563), was a French general and statesman. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.

  6. Feb 11, 2009 · Extract. François due de Guise, commander of the French catholic forces, was assaulted by Poltrot de Mérey (or Méré) before Orléans on 18 February 1563. He succumbed six days later, on 24 February, to the attentions of his surgeons, whose lethal ministrations are horribly retailed by the Spanish ambassador, Chantonnay.

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  8. The conflict between the Guise family and the king started to escalate after the death of Henry III’s younger brother Francis, the Duke of Alençon, in the Netherlands on June 19, 1584. Despite medical attempts to “cure” the royal couple, Henry III and Louise of Lorraine could not produce an heir to the throne.

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