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Oct 1, 2024 · Viral infectivity factor (Vif) has been recognized as a new therapeutic target for human immunodeficiency virus-1 (HIV-1) infected patients. In our previous work, we have synthesized a novel class of Vif inhibitors with 2-amino-N- (5-hydroxy-2-methoxyphenyl)-6- ( (4-nitrophenyl)thio)benzamide scaffold, which show obvious activity in HIV-1 ...
Oct 8, 2024 · While most of what we are doing would be normal science, some discoveries were revolutionary in nature, e.g. in cardiology, William Harvey’s ‘De motu Cordis’, 16 the description of the double-stranded DNA, 17 the cholesterol hypothesis, 18 and the open-artery hypothesis for acute myocardial infarction. Could algorithms spot the holes in our knowledge base, produce new hypotheses within ...
Sep 20, 2024 · The Centre for Medical Informatics (CMI) is led by Heads of Centre Professor Ewen Harrison and Professor Julie Jacko. Full list of Centre for Medical Informatics staff. Usher PhD and MD students listed by programme.
Sep 24, 2024 · Despite the popularity of Variance Inflation Factor (VIF) scores as multicollinearity diagnostics, methodological work has voiced skepticism. In a paper that has become the most highly cited reference regarding the use of VIF scores, O’Brien urged caution when applying VIF thresholds.
Sep 30, 2024 · In brief, the HIV Vif protein will prevent APOBEC3G from being encapsulated by virus particles. Although APOBEC3G is a member of a family of cellular enzymes termed cytidine deaminases, it seems to be unique in regard to its ability to interact with and be antagonized by Vif, which is a virus-encoded cytoplasmic protein.
Sep 21, 2024 · Science-based knowledge, not narrative-dictated knowledge, is the goal of WSES, and we will work to make sure that only objective knowledge is used in the formation of medical standards of care and public health policies.
Oct 3, 2024 · The Summit will provide opportunities to learn about data-driven policy solutions to address Ohio’s greatest health challenges and support the development of new evidence through innovation.
